Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers - Huseman, Eric D.; Lo, Anna; Fedorova, Olga; Elia, James L.; Gueble, Susan E.; Lin, Kingson; Sundaram, Ranjini K.; Oh, Joonseok; Liu, Jinchan; Menges, Fabian; Rees, Matthew G.; Ronan, Melissa M.; et al. (Journal of the American Chemical Society, 2024)
Keywords: alkylation; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; brain; Brain Neoplasms - drug therapy; Brain Neoplasms - pathology; Cell Line, Tumor; crosslinking; cytidine; DNA; DNA repair; DNA Repair - drug effects; drug resistance; Drug Resistance, Neoplasm - drug effects; fluorides; Humans; Imidazoles - chemistry; Imidazoles - pharmacology; Imidazoles - therapeutic use; mechanism of action; mutagens; O-Methylguanine-DNA Methyltransferase - antagonists & inhibitors; O-Methylguanine-DNA Methyltransferase - metabolism; toxicity; toxins