Simplified Modular Access to Enantiopure 1,2-Aminoalcohols via Ni-Electrocatalytic Decarboxylative Arylation

• Published in: Journal of the American Chemical Society Vol. 146; no. 9; pp. 6209 - 6216
• Main Authors: Sun, Jiawei, Endo, Hirofumi, Emmanuel, Megan A., Oderinde, Martins S., Kawamata, Yu, Baran, Phil S.
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 22.02.2024
• Subjects: amino alcohols; arylation; carboxylic acids; enantiomers; stereochemistry; stereoselectivity

Chiral aminoalcohols are omnipresent in bioactive compounds. Conventional strategies to access this motif involve multiple-step reactions to install the requisite functionalities stereoselectively using conventional polar bond analysis. This study reveals that a simple chiral oxazolidine-based carbo...