Characterization of high-level daptomycin resistance in Viridans group Streptococci developed upon in vitro exposure to daptomycin

• Published in: Antimicrobial agents and chemotherapy Vol. 59; no. 4; pp. 2102 - 2112
• Main Authors: Akins, Ronda L, Katz, Bradley D, Monahan, Catherine, Alexander, Dylan
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.04.2015
• Subjects: Anti-Bacterial Agents; Anti-Bacterial Agents - pharmacology; Bacteremia - microbiology; Calcium - metabolism; Colony Count, Microbial; Daptomycin; Daptomycin - pharmacology; Drug Resistance, Bacterial; Drug Synergism; Endocarditis, Bacterial - microbiology; Humans; Mechanisms of Resistance; Microbial Sensitivity Tests; Streptococcal Infections - microbiology; Streptococcus gordonii; Streptococcus gordonii - drug effects; Viridans Streptococci; Viridans Streptococci - drug effects

Viridans group streptococci (VGS) are part of the normal flora that may cause bacteremia, often leading to endocarditis. We evaluated daptomycin against four clinical strains of VGS (MICs = 1 or 2 μg/ml) using an in vitro-simulated endocardial vegetation model, a simulated bacteremia model, and kill...