Evaluating the Pharmacodynamic Effect of Antimalarial Drugs in Clinical Trials by Quantitative PCR

• Published in: Antimicrobial agents and chemotherapy Vol. 59; no. 7; pp. 4249 - 4259
• Main Authors: Marquart, Louise, Baker, Mark, O'Rourke, Peter, McCarthy, James S.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.07.2015
• Subjects: Adolescent; Adult; Algorithms; Antimalarials; Antimalarials - adverse effects; Antimalarials - pharmacokinetics; Antimalarials - therapeutic use; Area Under Curve; Drug Combinations; Female; Half-Life; Humans; Malaria; Malaria - drug therapy; Malaria - parasitology; Male; Mefloquine - adverse effects; Mefloquine - pharmacokinetics; Mefloquine - therapeutic use; Models, Statistical; Parasitemia - drug therapy; Parasitemia - parasitology; Pharmacology; Polymerase Chain Reaction; Polymerase Chain Reaction - methods; Pyrimethamine - adverse effects; Pyrimethamine - pharmacokinetics; Pyrimethamine - therapeutic use; Reproducibility of Results; Sulfadoxine - adverse effects; Sulfadoxine - pharmacokinetics; Sulfadoxine - therapeutic use; Young Adult; Australia; PSE, New Zealand

The ongoing development of new antimalarial drugs and the increasing use of controlled human malaria infection (CHMI) studies to investigate their activity in early-stage clinical trials require the development of methods to analyze their pharmacodynamic effect. This is especially so for studies whe...