Staphylococcus aureus Alpha-Toxin Is Conserved among Diverse Hospital Respiratory Isolates Collected from a Global Surveillance Study and Is Neutralized by Monoclonal Antibody MEDI4893

• Published in: Antimicrobial agents and chemotherapy Vol. 60; no. 9; pp. 5312 - 5321
• Main Authors: Tabor, David E., Yu, Li, Mok, Hoyin, Tkaczyk, Christine, Sellman, Bret R., Wu, Yuling, Oganesyan, Vaheh, Slidel, Tim, Jafri, Hasan, McCarthy, Michael, Bradford, Patricia, Esser, Mark T.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.09.2016
• Subjects: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Amino Acid Sequence; Anti-Inflammatory Agents; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Antibodies, Monoclonal; Antibodies, Monoclonal - chemistry; Antibodies, Monoclonal - pharmacology; Antibodies, Neutralizing; Antibodies, Neutralizing - chemistry; Antibodies, Neutralizing - pharmacology; Bacterial Toxins; Bacterial Toxins - antagonists & inhibitors; Bacterial Toxins - chemistry; Bacterial Toxins - genetics; Bacterial Toxins - immunology; Child; Child, Preschool; Conserved Sequence; Epidemiological Monitoring; Epidemiology and Surveillance; Female; Global Health; Hemolysin Proteins; Hemolysin Proteins - antagonists & inhibitors; Hemolysin Proteins - chemistry; Hemolysin Proteins - genetics; Hemolysin Proteins - immunology; Humans; Infant; Infant, Newborn; Length of Stay - statistics & numerical data; Male; Middle Aged; Models, Molecular; Mutation; Pneumonia, Ventilator-Associated; Pneumonia, Ventilator-Associated - epidemiology; Pneumonia, Ventilator-Associated - microbiology; Pneumonia, Ventilator-Associated - pathology; Pneumonia, Ventilator-Associated - prevention & control; Protein Conformation; Sequence Analysis, DNA; Staphylococcal Infections; Staphylococcal Infections - drug therapy; Staphylococcal Infections - epidemiology; Staphylococcal Infections - microbiology; Staphylococcal Infections - pathology; Staphylococcus aureus; Staphylococcus aureus - drug effects; Staphylococcus aureus - genetics; Staphylococcus aureus - immunology; Staphylococcus aureus - isolation & purification

Staphylococcus aureus infections lead to an array of illnesses ranging from mild skin infections to serious diseases, such endocarditis, osteomyelitis, and pneumonia. Alpha-toxin (Hla) is a pore-forming toxin, encoded by the hla gene, that is thought to play a key role in S. aureus pathogenesis. A m...