Staphylococcus aureus Alpha-Toxin Is Conserved among Diverse Hospital Respiratory Isolates Collected from a Global Surveillance Study and Is Neutralized by Monoclonal Antibody MEDI4893 - Tabor, David E.; Yu, Li; Mok, Hoyin; Tkaczyk, Christine; Sellman, Bret R.; Wu, Yuling; Oganesyan, Vaheh; Slidel, Tim; Jafri, Hasan; McCarthy, Michael; Bradford, Patricia; Esser, Mark T. (Antimicrobial agents and chemotherapy, 2016)
Keywords: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Amino Acid Sequence; Anti-Inflammatory Agents; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Antibodies, Monoclonal; Antibodies, Monoclonal - chemistry; Antibodies, Monoclonal - pharmacology; Antibodies, Neutralizing; Antibodies, Neutralizing - chemistry; Antibodies, Neutralizing - pharmacology; Bacterial Toxins; Bacterial Toxins - antagonists & inhibitors; Bacterial Toxins - chemistry; Bacterial Toxins - genetics; Bacterial Toxins - immunology; Child; Child, Preschool; Conserved Sequence; Epidemiological Monitoring; Epidemiology and Surveillance; Female; Global Health; Hemolysin Proteins; Hemolysin Proteins - antagonists & inhibitors; Hemolysin Proteins - chemistry; Hemolysin Proteins - genetics; Hemolysin Proteins - immunology; Humans; Infant; Infant, Newborn; Length of Stay - statistics & numerical data; Male; Middle Aged; Models, Molecular; Mutation; Pneumonia, Ventilator-Associated; Pneumonia, Ventilator-Associated - epidemiology; Pneumonia, Ventilator-Associated - microbiology; Pneumonia, Ventilator-Associated - pathology; Pneumonia, Ventilator-Associated - prevention & control; Protein Conformation; Sequence Analysis, DNA; Staphylococcal Infections; Staphylococcal Infections - drug therapy; Staphylococcal Infections - epidemiology; Staphylococcal Infections - microbiology; Staphylococcal Infections - pathology; Staphylococcus aureus; Staphylococcus aureus - drug effects; Staphylococcus aureus - genetics; Staphylococcus aureus - immunology; Staphylococcus aureus - isolation & purification