A population pharmacokinetic modeling approach shows that serum penicillin G concentrations are below inhibitory concentrations by two weeks after benzathine penicillin G injection in the majority of young adults

• Published in: Antimicrobial agents and chemotherapy Vol. 58; no. 11; pp. 6735 - 6741
• Main Authors: Neely, Michael, Kaplan, Edward L, Blumer, Jeffrey L, Faix, Dennis J, Broderick, Michael P
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.11.2014
• Subjects: Adolescent; Adult; Anti-Bacterial Agents; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - pharmacokinetics; Humans; Male; Microbial Sensitivity Tests; Penicillin G Benzathine; Penicillin G Benzathine - blood; Penicillin G Benzathine - metabolism; Penicillin G Benzathine - pharmacokinetics; Pharmacology; Respiratory Tract Infections - drug therapy; Respiratory Tract Infections - microbiology; Rheumatic Heart Disease - microbiology; Rheumatic Heart Disease - prevention & control; Streptococcus pyogenes; Streptococcus pyogenes - drug effects; Syphilis - drug therapy; Syphilis - microbiology; Young Adult

Serum penicillin G falls to low levels 2 weeks after injection as benzathine penicillin G (BPG) in young adults. Using Pmetrics and previously reported penicillin G pharmacokinetic data after 1.2 million units were given as BPG to 329 male military recruits, here we develop the first reported popula...