Penetration of Ceftaroline into the Epithelial Lining Fluid of Healthy Adult Subjects

• Published in: Antimicrobial agents and chemotherapy Vol. 60; no. 10; pp. 5849 - 5857
• Main Authors: Riccobene, Todd A., Pushkin, Richard, Jandourek, Alena, Knebel, William, Khariton, Tatiana
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.10.2016
• Subjects: Adult; Bronchoalveolar Lavage Fluid; Bronchoalveolar Lavage Fluid - cytology; Ceftaroline; Cephalosporins; Cephalosporins - administration & dosage; Cephalosporins - blood; Cephalosporins - pharmacokinetics; Epithelial Cells - drug effects; Experimental Therapeutics; Female; Healthy Volunteers; Humans; Injections, Intravenous; Male; Staphylococcus aureus

Ceftaroline, the active metabolite of the prodrug ceftaroline fosamil, is a cephalosporin with bactericidal activity against Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA). This study aimed to (i) evaluate ceftaroline concentrations in human plasma and epitheli...