Therapeutic Protein–Polymer Conjugates: Advancing Beyond PEGylation

• Published in: Journal of the American Chemical Society Vol. 136; no. 41; pp. 14323 - 14332
• Main Authors: Pelegri-O’Day, Emma M, Lin, En-Wei, Maynard, Heather D
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 15.10.2014
• Subjects: blood flow; chemical bonding; developmental stages; drugs; Food and Drug Administration; half life; Models, Molecular; Molecular Structure; patients; pharmacokinetics; polyethylene glycol; Polyethylene Glycols - chemistry; Polyethylene Glycols - therapeutic use; Polymerization; Proteins - chemistry; Proteins - metabolism; therapeutics

Protein–polymer conjugates are widely used as therapeutics. All Food and Drug Administration (FDA)-approved protein conjugates are covalently linked to poly­(ethylene glycol) (PEG). These PEGylated drugs have longer half-lives in the bloodstream, leading to less frequent dosing, which is a significa...