Targeting Multiple Aminoacyl-tRNA Synthetases Overcomes the Resistance Liabilities Associated with Antibacterial Inhibitors Acting on a Single Such Enzyme - Randall, Christopher P.; Rasina, Dace; Jirgensons, Aigars; O'Neill, Alex J. (Antimicrobial agents and chemotherapy, 2016)
Keywords: Amino Acyl-tRNA Synthetases; Amino Acyl-tRNA Synthetases - antagonists & inhibitors; Anti-Bacterial Agents; Anti-Bacterial Agents - pharmacology; Boron Compounds - pharmacology; Diamines - pharmacology; Drug Resistance, Bacterial; Drug Resistance, Bacterial - drug effects; Enzyme Inhibitors; Enzyme Inhibitors - pharmacology; Mechanisms of Resistance; Microbial Sensitivity Tests; Molecular Targeted Therapy; Mupirocin - pharmacology; Mutation Rate; Staphylococcus aureus; Staphylococcus aureus - drug effects; Staphylococcus aureus - genetics; Thiophenes - pharmacology