Metabolic Profiling Regarding Pathogenesis of Idiopathic Pulmonary Fibrosis

• Published in: Journal of proteome research Vol. 15; no. 5; pp. 1717 - 1724
• Main Authors: Kang, Yun Pyo, Lee, Sae Bom, Lee, Ji-min, Kim, Hyung Min, Hong, Ji Yeon, Lee, Won Jun, Choi, Chang Woo, Shin, Hwa Kyun, Kim, Do-Jin, Koh, Eun Suk, Park, Choon-Sik, Kwon, Sung Won, Park, Sung-Woo
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 06.05.2016
• Subjects: adenosine triphosphate; biochemical pathways; biomarkers; biosynthesis; Case-Control Studies; Cells, Cultured; Discriminant Analysis; epithelial cells; extracellular matrix; fibroblasts; fibrosis; Gas Chromatography-Mass Spectrometry; glutathione; glycolysis; Humans; Idiopathic Pulmonary Fibrosis - metabolism; Idiopathic Pulmonary Fibrosis - pathology; least squares; lung function; lungs; Metabolic Networks and Pathways; metabolites; metabolomics; Metabolomics - methods; Myofibroblasts - metabolism; Myofibroblasts - pathology; ornithine-oxo-acid transaminase; parenchyma (animal tissue); pathogenesis; patients; proteins; proteome; idiopathic pulmonary fibrosis; gas chromatography−mass spectrometry (GC−MS); metabolic profiling; lung tissue

Idiopathic pulmonary fibrosis (IPF) is a progressive, eventually fatal disease characterized by fibrosis of the lung parenchyma and loss of lung function. IPF is believed to be caused by repetitive alveolar epithelial cell injury and dysregulated repair process including uncontrolled proliferation o...