Creation of a Peptide Antagonist of the GFRAL–RET Receptor Complex for the Treatment of GDF15-Induced Malaise

• Published in: Journal of medicinal chemistry Vol. 66; no. 16; pp. 11237 - 11249
• Main Authors: Borner, Tito, Tinsley, Ian C., Milliken, Brandon T., Doebley, Sarah A., Najjar, Nicholas R., Kerwood, Deborah J., De Jonghe, Bart C., Hayes, Matthew R., Doyle, Robert P.
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 24.08.2023
• Subjects: Animals; Anorexia - metabolism; Cell Membrane - metabolism; Cisplatin - therapeutic use; Growth Differentiation Factor 15 - antagonists & inhibitors; Growth Differentiation Factor 15 - metabolism; Growth Differentiation Factor 15 - pharmacology; Rats

Growth differentiation factor 15 (GDF15) is a contributor to nausea, emesis, and anorexia following chemotherapy via binding to the GFRAL-RET receptor complex expressed in hindbrain neurons. Therefore, GDF15-mediated GFRAL-RET signaling is a promising target for improving treatment outcomes for chem...