Total Synthesis of Tagetitoxin

• Published in: Journal of the American Chemical Society Vol. 142; no. 32; pp. 13683 - 13688
• Main Authors: He, Chi, Chu, Hang, Stratton, Thomas P, Kossler, David, Eberle, Kelly J, Flood, Dillon T, Baran, Phil S
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 12.08.2020; Amer Chemical Soc
• Subjects: bioassays; Chemistry; Chemistry, Multidisciplinary; Dicarboxylic Acids - chemical synthesis; Dicarboxylic Acids - chemistry; enantiomers; furans; Molecular Structure; Organophosphorus Compounds - chemical synthesis; Organophosphorus Compounds - chemistry; phosphates; Physical Sciences; Science & Technology; Stereoisomerism; REARRANGEMENT; CORE; OXATHIAPHOSPHOLANE APPROACH; CONVERSION; AMINO; TRANSCRIPTION; SINGLET OXYGEN; DERIVATIVES

The intriguing structure of tagetitoxin (1), a long-standing challenge in natural product synthesis, has been the subject of multiple revisions and has been confirmed through total synthesis. The route commences from a renewable furan starting material and features a number of unusual transformation...