Siglecs as Immune Cell Checkpoints in Disease

• Published in: Annual review of immunology Vol. 38; p. 365
• Main Authors: Duan, Shiteng, Paulson, James C
• Format: Journal Article
• Language: English
• Published: United States 26.04.2020
• Subjects: B cell; Siglec; Alzheimer disease; T cell; cancer; CD22; CD33; lymphocyte

Sialic acid-binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of white blood cells of the immune system and play critical roles in immune cell signaling. Through recognition of sialic acid-containing glycans as ligands, they help the immune system distinguish between self a...