Siglecs as Immune Cell Checkpoints in Disease
Sialic acid-binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of white blood cells of the immune system and play critical roles in immune cell signaling. Through recognition of sialic acid-containing glycans as ligands, they help the immune system distinguish between self a...
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| Published in | Annual review of immunology Vol. 38; p. 365 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
26.04.2020
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| Subjects | |
| Online Access | Get more information |
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| Abstract | Sialic acid-binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of white blood cells of the immune system and play critical roles in immune cell signaling. Through recognition of sialic acid-containing glycans as ligands, they help the immune system distinguish between self and nonself. Because of their restricted cell type expression and roles as checkpoints in immune cell responses in human diseases such as cancer, asthma, allergy, neurodegeneration, and autoimmune diseases they have gained attention as targets for therapeutic interventions. In this review we describe the Siglec family, its roles in regulation of immune cell signaling, current efforts to define its roles in disease processes, and approaches to target Siglecs for treatment of human disease. |
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| AbstractList | Sialic acid-binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of white blood cells of the immune system and play critical roles in immune cell signaling. Through recognition of sialic acid-containing glycans as ligands, they help the immune system distinguish between self and nonself. Because of their restricted cell type expression and roles as checkpoints in immune cell responses in human diseases such as cancer, asthma, allergy, neurodegeneration, and autoimmune diseases they have gained attention as targets for therapeutic interventions. In this review we describe the Siglec family, its roles in regulation of immune cell signaling, current efforts to define its roles in disease processes, and approaches to target Siglecs for treatment of human disease. |
| Author | Duan, Shiteng Paulson, James C |
| Author_xml | – sequence: 1 givenname: Shiteng surname: Duan fullname: Duan, Shiteng email: jpaulson@scripps.edu organization: Departments of Molecular Medicine, and Immunology and Microbiology, Scripps Research, La Jolla, California 92037, USA; email: jpaulson@scripps.edu – sequence: 2 givenname: James C surname: Paulson fullname: Paulson, James C email: jpaulson@scripps.edu organization: Departments of Molecular Medicine, and Immunology and Microbiology, Scripps Research, La Jolla, California 92037, USA; email: jpaulson@scripps.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31986070$$D View this record in MEDLINE/PubMed |
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