Brain morphometric biomarkers distinguishing unipolar and bipolar depression. A voxel-based morphometry-pattern classification approach

• Published in: JAMA psychiatry (Chicago, Ill.) Vol. 71; no. 11; p. 1222
• Main Authors: Redlich, Ronny, Almeida, Jorge J R, Grotegerd, Dominik, Opel, Nils, Kugel, Harald, Heindel, Walter, Arolt, Volker, Phillips, Mary L, Dannlowski, Udo
• Format: Journal Article
• Language: English
• Published: United States 01.11.2014
• Subjects: Adult; Atrophy - pathology; Biomarkers; Bipolar Disorder - diagnosis; Bipolar Disorder - pathology; Case-Control Studies; Cross-Sectional Studies; Depressive Disorder - diagnosis; Depressive Disorder - pathology; Diagnosis, Differential; Female; Gray Matter - pathology; Humans; Magnetic Resonance Imaging; Male; Neuroimaging; White Matter - pathology; Young Adult

The structural abnormalities in the brain that accurately differentiate unipolar depression (UD) and bipolar depression (BD) remain unidentified. First, to investigate and compare morphometric changes in UD and BD, and to replicate the findings at 2 independent neuroimaging sites; second, to differe...