Analogues of the Potent Antitumor Compound Leiodermatolide from a Deep-Water Sponge of the Genus Leiodermatium

• Published in: Journal of natural products (Washington, D.C.) Vol. 80; no. 3; pp. 735 - 739
• Main Authors: Wright, Amy E, Roberts, Jill C, Guzmán, Esther A, Pitts, Tara P, Pomponi, Shirley A, Reed, John K
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society and American Society of Pharmacognosy 24.03.2017; Amer Chemical Soc
• Subjects: Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Chemistry, Medicinal; Drug Screening Assays, Antitumor; Florida; Humans; Life Sciences & Biomedicine; Macrolides - chemistry; Macrolides - isolation & purification; Macrolides - pharmacology; Molecular Structure; Pharmacology & Pharmacy; Plant Sciences; Porifera - chemistry; Science & Technology; CORE; MACROLIDE

Two new analogues of the potent antitumor compound leiodermatolide, which we call leiodermatolides B and C, have been isolated from specimens of a deep-water sponge of the genus Leiodermatium collected off Florida. The compounds were purified using standard chromatographic methods, and the structure...