Polyprodrug Amphiphiles: Hierarchical Assemblies for Shape-Regulated Cellular Internalization, Trafficking, and Drug Delivery

• Published in: Journal of the American Chemical Society Vol. 135; no. 46; pp. 17617 - 17629
• Main Authors: Hu, Xianglong, Hu, Jinming, Tian, Jie, Ge, Zhishen, Zhang, Guoying, Luo, Kaifu, Liu, Shiyong
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 20.11.2013; Amer Chemical Soc
• Subjects: Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antineoplastic Agents, Phytogenic - administration & dosage; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; blood circulation; Camptothecin - administration & dosage; Camptothecin - chemistry; Camptothecin - pharmacology; Cell Line, Tumor; Cell Survival - drug effects; Chemistry; Chemistry, Multidisciplinary; composite polymers; cytotoxicity; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Screening Assays, Antitumor; drugs; Hep G2 Cells; Humans; Kinetics; Molecular Structure; nanomaterials; Nanostructures - chemistry; Particle Size; Physical Sciences; polyethylene glycol; polymerization; Polymers - administration & dosage; Polymers - chemistry; Polymers - pharmacology; Prodrugs - administration & dosage; Prodrugs - chemistry; Prodrugs - pharmacology; Science & Technology; Structure-Activity Relationship; Surface Properties; DIBLOCK COPOLYMERS; NANOPARTICLES; CELLS; SPHERICAL-PARTICLES; DESIGN; ACID) BLOCK-COPOLYMERS; DOXORUBICIN; DISK-LIKE MICELLES; CARRIERS; CANCER

Solution self-assembly of block copolymers (BCPs) typically generates spheres, rods, and vesicles. The reproducible bottom-up fabrication of stable planar nanostructures remains elusive due to their tendency to bend into closed bilayers. This morphological vacancy renders the study of shape effects...