Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release - Daniel, Kevin B; Sullivan, Eric D; Chen, Yao; Chan, Joshua C; Jennings, Patricia A; Fierke, Carol A; Cohen, Seth M (Journal of medicinal chemistry, 2015)
Keywords: Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Blotting, Western; Cell Proliferation - drug effects; Cells, Cultured; Chromatography, Liquid; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - enzymology; Histone Deacetylase Inhibitors - chemistry; Histone Deacetylase Inhibitors - pharmacology; Histone Deacetylases; Humans; Hydroxamic Acids - chemistry; Hydroxamic Acids - pharmacology; Leukemia, T-Cell - drug therapy; Leukemia, T-Cell - enzymology; Leukemia, T-Cell - pathology; Mice; Models, Molecular; Molecular Structure; Prodrugs - chemistry; Prodrugs - pharmacology; Repressor Proteins - antagonists & inhibitors; Structure-Activity Relationship; Tandem Mass Spectrometry