Programmable Bispecific Nano-immunoengager That Captures T Cells and Reprograms Tumor Microenvironment

• Published in: Nano letters Vol. 22; no. 17; pp. 6866 - 6876
• Main Authors: Zhang, Lu, Bo, Ruonan, Wu, Yi, Li, Longmeng, Zhu, Zheng, Ma, Ai-Hong, Xiao, Wenwu, Huang, Yanyu, Rojalin, Tatu, Yin, Xingbin, Mao, Chunping, Wang, Fengyi, Wang, Yongheng, Zhang, Hongyong, Low, Kelmen E., Lee, Kiana, Ajena, Yousif, Jing, Di, Zhang, Dalin, Baehr, Christopher M., Liu, Ruiwu, Wang , Lei, Li , Yuanpei, Lam, Kit S.
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 14.09.2022
• Subjects: Animals; Immunomodulation; Integrins; Letter; Mice; Neoplasms - drug therapy; T-Lymphocytes; Tumor Microenvironment; nano-immuno-engager; immune checkpoint blockade (ICB) therapy; fibrillar transformation; T cells capture
• ISSN: 1530-6984; 1530-6992; 1530-6992
• DOI: 10.1021/acs.nanolett.2c00582

Immune checkpoint blockade (ICB) therapy has revolutionized clinical oncology. However, the efficacy of ICB therapy is limited by the ineffective infiltration of T effector (Teff) cells to tumors and the immunosuppressive tumor microenvironment (TME). Here, we report a programmable tumor cells/Teff...