Cinnamoyloxy-mammeisin Isolated from Geopropolis Attenuates Inflammatory Process by Inhibiting Cytokine Production: Involvement of MAPK, AP-1, and NF-κB

• Published in: Journal of natural products (Washington, D.C.) Vol. 79; no. 7; pp. 1828 - 1833
• Main Authors: Franchin, Marcelo, Rosalen, Pedro Luiz, da Cunha, Marcos Guilherme, Silva, Rangel Leal, Colón, David F, Bassi, Gabriel Shimizu, de Alencar, Severino Matias, Ikegaki, Masaharu, Alves-Filho, José C, Cunha, Fernando Q, Beutler, John A, Cunha, Thiago Mattar
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society and American Society of Pharmacognosy 22.07.2016
• Subjects: Animals; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; Brazil; Coumarins - chemistry; Coumarins - isolation & purification; Coumarins - pharmacology; Cyclooxygenase 2 - metabolism; eIF-2 Kinase - drug effects; Lipopolysaccharides - pharmacology; Macrophages - metabolism; Mice; Molecular Structure; NF-kappa B - antagonists & inhibitors; Nitric Oxide Synthase Type II - antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases - metabolism; Signal Transduction - drug effects; Transcription Factor AP-1; Tumor Necrosis Factor-alpha - pharmacology

Chemical compounds belonging to the class of coumarins have promising anti-inflammatory potential. Cinnamoyloxy-mammeisin (CNM) is a 4-phenylcoumarin that can be isolated from Brazilian geopropolis. To our knowledge, its anti-inflammatory activity has never been studied. Therefore, the present study...