Observation of inverted cubic phase in hydrated dioleoylphosphatidylethanolamine membranes

• Published in: Biochemistry (Easton) Vol. 27; no. 7; pp. 2332 - 2336
• Main Authors: Shyamsunder, E, Gruner, Sol M, Tate, M. W, Turner, D. C, So, P. T. C, Tilcock, C. P. S
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 05.04.1988
• Subjects: Biological and medical sciences; Disperse state. Micelles; Fundamental and applied biological sciences. Psychology; Models, Biological; Molecular biophysics; Molecular Conformation; Phosphatidylethanolamines; Physico-chemical properties of biomolecules; Water; X-Ray Diffraction; Dispersed state; Phospholipid; Small angle X ray scattering; Phase transitions; Mesomorphic state

We report the observation of an inverted cubic phase in aqueous dispersions of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) by small-angle X-ray diffraction. DOPE is a paradigm in the study of nonlamellar phases in biological systems: it exhibits a well-known phase transition from the lamell...