Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA) - Abdeen, Sanofar; Kunkle, Trent; Salim, Nilshad; Ray, Anne-Marie; Mammadova, Najiba; Summers, Corey; Stevens, Mckayla; Ambrose, Andrew J.; Park, Yangshin; Schultz, Peter G.; Horwich, Arthur L.; Hoang, Quyen Q.; et al. (Journal of medicinal chemistry, 2018)
Keywords: Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Bacterial Proteins - antagonists & inhibitors; Calorimetry - methods; Cell Line; Cell Survival - drug effects; Chaperonin 10 - antagonists & inhibitors; Chaperonin 10 - chemistry; Chaperonin 10 - metabolism; Chaperonin 60 - antagonists & inhibitors; Chemistry, Medicinal; Drug Evaluation, Preclinical - methods; Gram-Negative Bacteria - drug effects; Gram-Positive Bacteria - drug effects; Humans; Life Sciences & Biomedicine; Methicillin-Resistant Staphylococcus aureus - drug effects; Microbial Sensitivity Tests; Pharmacology & Pharmacy; Science & Technology; Structure-Activity Relationship; Sulfonamides - chemistry; Thiophenes - chemistry; CHAPERONIN GROEL; PROTEIN; TRANSTHYRETIN AMYLOIDOGENESIS INHIBITORS; SUBSTRUCTURE COMMON; OPTIMIZATION; ESKAPE PATHOGENS; ANTIMICROBIAL RESISTANCE; BINDING; DISCOVERY