Serum Endoglin Levels in Patients Suffering from Systemic Sclerosis and Elevated Systolic Pulmonary Arterial Pressure
Background. Pulmonary arterial hypertension (PAH) is the main cause of morbimortality in systemic sclerosis (SSc). Increased Eng expression has been demonstrated in SSc patients. Objective. Ascertaining serum levels of Eng in SSc patients with and without elevated systolic pulmonary arterial pressur...
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| Published in | International Journal of Rheumatology Vol. 2010; no. 2010; pp. 152 - 157 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cairo, Egypt
Hindawi Limiteds
2010
Hindawi Puplishing Corporation Hindawi Publishing Corporation John Wiley & Sons, Inc |
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| Online Access | Get full text |
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| Abstract | Background. Pulmonary arterial hypertension (PAH) is the main cause of morbimortality in systemic sclerosis (SSc). Increased Eng expression has been demonstrated in SSc patients. Objective. Ascertaining serum levels of Eng in SSc patients with and without elevated systolic pulmonary arterial pressure (sPAP) and comparing them with that of healthy volunteers. Methods. A cross-sectional study was carried out. A commercial ELISA kit was used for measuring serum concentrations of Eng in 60 subjects: 40 patients with SSc with and without elevated sPAP, compared to 20 healthy control subjects. Elevated sPAP was detected by echocardiogram. Results. No association between positive Eng and elevated sPAP was found when compared to the SSc without elevated sPAP group (OR=2.85; 0.65–12.88 95% CI; P=.11); however, an association was found between positive Eng and elevated sPAP compared to healthy controls (OR=23.22; 2.46–1050.33 95% CI; P=.001), and weak association was found between the positive Eng with SSc without elevated sPAP group compared to healthy controls (OR=8.14, 0.8–393.74 95% CI; P=.046). Conclusion. Raised serum levels of Eng in SSc patients compared to healthy controls were found, suggesting a role for Eng in SSc vasculopathy and not just in elevated sPAP. However, prospective studies are needed to verify such observations. |
|---|---|
| AbstractList | Background
. Pulmonary arterial hypertension (PAH) is the main cause of morbimortality in systemic sclerosis (SSc). Increased Eng expression has been demonstrated in SSc patients.
Objective
. Ascertaining serum levels of Eng in SSc patients with and without elevated systolic pulmonary arterial pressure (sPAP) and comparing them with that of healthy volunteers.
Methods
. A cross-sectional study was carried out. A commercial ELISA kit was used for measuring serum concentrations of Eng in 60 subjects: 40 patients with SSc with and without elevated sPAP, compared to 20 healthy control subjects. Elevated sPAP was detected by echocardiogram.
Results
. No association between positive Eng and elevated sPAP was found when compared to the SSc without elevated sPAP group (OR = 2.85; 0.65–12.88 95% CI;
P
= .11); however, an association was found between positive Eng and elevated sPAP compared to healthy controls (OR = 23.22; 2.46–1050.33 95% CI;
P
= .001), and weak association was found between the positive Eng with SSc without elevated sPAP group compared to healthy controls (OR = 8.14, 0.8–393.74 95% CI;
P
= .046).
Conclusion
. Raised serum levels of Eng in SSc patients compared to healthy controls were found, suggesting a role for Eng in SSc vasculopathy and not just in elevated sPAP. However, prospective studies are needed to verify such observations. Background. Pulmonary arterial hypertension (PAH) is the main cause of morbimortality in systemic sclerosis (SSc). Increased Eng expression has been demonstrated in SSc patients. Objective. Ascertaining serum levels of Eng in SSc patients with and without elevated systolic pulmonary arterial pressure (sPAP) and comparing them with that of healthy volunteers. Methods. A cross-sectional study was carried out. A commercial ELISA kit was used for measuring serum concentrations of Eng in 60 subjects: 40 patients with SSc with and without elevated sPAP, compared to 20 healthy control subjects. Elevated sPAP was detected by echocardiogram. Results. No association between positive Eng and elevated sPAP was found when compared to the SSc without elevated sPAP group (OR = 2.85; 0.65-12.88 95% CI; P = .11); however, an association was found between positive Eng and elevated sPAP compared to healthy controls (OR = 23.22; 2.46-1050.33 95% CI; P = .001), and weak association was found between the positive Eng with SSc without elevated sPAP group compared to healthy controls (OR = 8.14, 0.8-393.74 95% CI; P = .046). Conclusion. Raised serum levels of Eng in SSc patients compared to healthy controls were found, suggesting a role for Eng in SSc vasculopathy and not just in elevated sPAP. However, prospective studies are needed to verify such observations.Background. Pulmonary arterial hypertension (PAH) is the main cause of morbimortality in systemic sclerosis (SSc). Increased Eng expression has been demonstrated in SSc patients. Objective. Ascertaining serum levels of Eng in SSc patients with and without elevated systolic pulmonary arterial pressure (sPAP) and comparing them with that of healthy volunteers. Methods. A cross-sectional study was carried out. A commercial ELISA kit was used for measuring serum concentrations of Eng in 60 subjects: 40 patients with SSc with and without elevated sPAP, compared to 20 healthy control subjects. Elevated sPAP was detected by echocardiogram. Results. No association between positive Eng and elevated sPAP was found when compared to the SSc without elevated sPAP group (OR = 2.85; 0.65-12.88 95% CI; P = .11); however, an association was found between positive Eng and elevated sPAP compared to healthy controls (OR = 23.22; 2.46-1050.33 95% CI; P = .001), and weak association was found between the positive Eng with SSc without elevated sPAP group compared to healthy controls (OR = 8.14, 0.8-393.74 95% CI; P = .046). Conclusion. Raised serum levels of Eng in SSc patients compared to healthy controls were found, suggesting a role for Eng in SSc vasculopathy and not just in elevated sPAP. However, prospective studies are needed to verify such observations. Background. Pulmonary arterial hypertension (PAH) is the main cause of morbimortality in systemic sclerosis (SSc). Increased Eng expression has been demonstrated in SSc patients. Objective. Ascertaining serum levels of Eng in SSc patients with and without elevated systolic pulmonary arterial pressure (sPAP) and comparing them with that of healthy volunteers. Methods. A cross-sectional study was carried out. A commercial ELISA kit was used for measuring serum concentrations of Eng in 60 subjects: 40 patients with SSc with and without elevated sPAP, compared to 20 healthy control subjects. Elevated sPAP was detected by echocardiogram. Results. No association between positive Eng and elevated sPAP was found when compared to the SSc without elevated sPAP group (OR = 2.85; 0.65-12.88 95% CI; P = .11); however, an association was found between positive Eng and elevated sPAP compared to healthy controls (OR = 23.22; 2.46-1050.33 95% CI; P = .001), and weak association was found between the positive Eng with SSc without elevated sPAP group compared to healthy controls (OR = 8.14, 0.8-393.74 95% CI; P = .046). Conclusion. Raised serum levels of Eng in SSc patients compared to healthy controls were found, suggesting a role for Eng in SSc vasculopathy and not just in elevated sPAP. However, prospective studies are needed to verify such observations. Background . Pulmonary arterial hypertension (PAH) is the main cause of morbimortality in systemic sclerosis (SSc). Increased Eng expression has been demonstrated in SSc patients. Objective . Ascertaining serum levels of Eng in SSc patients with and without elevated systolic pulmonary arterial pressure (sPAP) and comparing them with that of healthy volunteers. Methods . A cross-sectional study was carried out. A commercial ELISA kit was used for measuring serum concentrations of Eng in 60 subjects: 40 patients with SSc with and without elevated sPAP, compared to 20 healthy control subjects. Elevated sPAP was detected by echocardiogram. Results . No association between positive Eng and elevated sPAP was found when compared to the SSc without elevated sPAP group ( OR = 2.85 ; 0.65–12.88 95% CI; P = .11 ); however, an association was found between positive Eng and elevated sPAP compared to healthy controls ( OR = 23.22 ; 2.46–1050.33 95% CI; P = .001 ), and weak association was found between the positive Eng with SSc without elevated sPAP group compared to healthy controls ( OR = 8.14 , 0.8–393.74 95% CI; P = .046 ). Conclusion . Raised serum levels of Eng in SSc patients compared to healthy controls were found, suggesting a role for Eng in SSc vasculopathy and not just in elevated sPAP. However, prospective studies are needed to verify such observations. |
| Author | Restrepo, José Félix Garces, Maria Fernanda Coral-Alvarado, Paola Ximena Caminos, Jorge Eduardo Iglesias-Gamarra, Antonio Quintana, Gerardo |
| AuthorAffiliation | 3 Biochemistry Unit, Universidad Nacional de Colombia, Bogotá, Colombia 1 Rheumatology Section, Fundación Santa Fe de Bogotá, School Medicine Universidad de los Andes, Bogotá, Colombia 2 Rheumatology Unit, Universidad Nacional de Colombia, Bogotá, Colombia |
| AuthorAffiliation_xml | – name: 1 Rheumatology Section, Fundación Santa Fe de Bogotá, School Medicine Universidad de los Andes, Bogotá, Colombia – name: 3 Biochemistry Unit, Universidad Nacional de Colombia, Bogotá, Colombia – name: 2 Rheumatology Unit, Universidad Nacional de Colombia, Bogotá, Colombia |
| Author_xml | – sequence: 1 fullname: Garces, Maria Fernanda – sequence: 2 fullname: Coral-Alvarado, Paola Ximena – sequence: 3 fullname: Caminos, Jorge Eduardo – sequence: 4 fullname: Iglesias-Gamarra, Antonio – sequence: 5 fullname: Restrepo, José Félix – sequence: 6 fullname: Quintana, Gerardo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20871866$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1002_cbin_12097 crossref_primary_10_1007_s00380_011_0163_z crossref_primary_10_1007_s10067_016_3219_8 crossref_primary_10_1007_s00018_020_03701_w crossref_primary_10_1016_j_autrev_2011_04_019 crossref_primary_10_1186_s43044_023_00395_w crossref_primary_10_1016_j_pharmthera_2012_06_001 crossref_primary_10_1002_jcp_22690 crossref_primary_10_3389_fmed_2018_00175 crossref_primary_10_1007_s10067_024_06936_1 crossref_primary_10_3389_fmed_2022_964526 |
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| ContentType | Journal Article |
| Contributor | Restrepo, José Félix Garces, Maria Fernanda Coral-Alvarado, Paola Ximena Caminos, Jorge Eduardo Iglesias-Gamarra, Antonio Quintana, Gerardo |
| Contributor_xml | – sequence: 1 fullname: Garces, Maria Fernanda – sequence: 2 fullname: Coral-Alvarado, Paola Ximena – sequence: 3 fullname: Caminos, Jorge Eduardo – sequence: 4 fullname: Iglesias-Gamarra, Antonio – sequence: 5 fullname: Restrepo, José Félix – sequence: 6 fullname: Quintana, Gerardo |
| Copyright | Copyright © 2010 Paola Ximena Coral-Alvarado et al. Copyright © 2010 Paola Ximena Coral-Alvarado et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2010 Paola Ximena Coral-Alvarado et al. 2010 |
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| Snippet | Background. Pulmonary arterial hypertension (PAH) is the main cause of morbimortality in systemic sclerosis (SSc). Increased Eng expression has been... Background . Pulmonary arterial hypertension (PAH) is the main cause of morbimortality in systemic sclerosis (SSc). Increased Eng expression has been... |
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| SubjectTerms | Apoptosis Biomarkers Clinical Study Extracellular matrix Fibroblasts Hypertension Lung diseases Medical prognosis Mortality Pathogenesis Patients Rheumatology Rodents Ultrasonic imaging |
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| Title | Serum Endoglin Levels in Patients Suffering from Systemic Sclerosis and Elevated Systolic Pulmonary Arterial Pressure |
| URI | https://www.airitilibrary.com/Article/Detail/P20151224010-201012-201709210023-201709210023-152-157 https://search.emarefa.net/detail/BIM-512272 https://dx.doi.org/10.1155/2010/969383 https://www.ncbi.nlm.nih.gov/pubmed/20871866 https://www.proquest.com/docview/1702995971 https://www.proquest.com/docview/755400653 https://pubmed.ncbi.nlm.nih.gov/PMC2943106 |
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