Mechanistic Applicability Domain Classification of a Local Lymph Node Assay Dataset for Skin Sensitization

• Published in: Chemical research in toxicology Vol. 20; no. 7; pp. 1019 - 1030
• Main Authors: Roberts, David W, Patlewicz, Grace, Kern, Petra S, Gerberick, Frank, Kimber, Ian, Dearman, Rebecca J, Ryan, Cindy A, Basketter, David A, Aptula, Aynur O
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.07.2007
• Subjects: Algorithms; Animal Testing Alternatives; Animals; Databases, Factual - classification; Databases, Factual - statistics & numerical data; Drug Eruptions - diagnosis; Drug Eruptions - etiology; Drug-Related Side Effects and Adverse Reactions; Humans; Local Lymph Node Assay; Mice; Molecular Structure; Pharmaceutical Preparations - administration & dosage; Pharmaceutical Preparations - chemistry; Quantitative Structure-Activity Relationship; Reproducibility of Results; Skin - drug effects; Skin - pathology; Toxicity Tests - methods; Toxicity Tests - trends

The goal of eliminating animal testing in the predictive identification of chemicals with the intrinsic ability to cause skin sensitization is an important target, the attainment of which has recently been brought into even sharper relief by the EU Cosmetics Directive and the requirements of the REA...