Synthesis of a Hexavalent Betulinic Acid Derivative as a Hemagglutinin-Targeted Influenza Virus Entry Inhibitor - Chen, Yingying; Wang, Xinchen; Zhu, Yinbiao; Si, Longlong; Zhang, Bo; Zhang, Yongmin; Zhang, Lihe; Zhou, Demin; Xiao, Sulong (Molecular pharmaceutics, 2020)
Keywords: A549 Cells; Animals; Antiviral Agents - chemical synthesis; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Biochemistry, Molecular Biology; Cyclodextrins - chemistry; Dogs; Hemagglutinins - chemistry; Hemagglutinins - metabolism; Humans; Influenza A Virus, H1N1 Subtype - drug effects; Influenza A Virus, H1N1 Subtype - metabolism; Influenza A Virus, H1N1 Subtype - pathogenicity; Influenza, Human - drug therapy; Inhibitory Concentration 50; Life Sciences; Madin Darby Canine Kidney Cells; Mass Spectrometry; Pentacyclic Triterpenes - chemistry; Protein Binding; Triazoles - chemical synthesis; Triazoles - chemistry; Triazoles - pharmacology; Triazoles - therapeutic use; Virus Internalization - drug effects; entry inhibitor; influenza virus; betulinic acid; α-cyclodextrin