Structure Activity Relationships of 5-, 6-, and 7-Methyl-Substituted Azepan-3-one Cathepsin K Inhibitors - Yamashita, Dennis S; Marquis, Robert W; Xie, Ren; Nidamarthy, Sirishkumar D; Oh, Hye-Ja; Jeong, Jae U; Erhard, Karl F; Ward, Keith W; Roethke, Theresa J; Smith, Brian R; Cheng, H-Y; Geng, Xiaoliu; et al. (Journal of medicinal chemistry, 2006)
Keywords: Animals; Azepines - chemical synthesis; Azepines - chemistry; Azepines - pharmacology; Biological and medical sciences; Biological Availability; Blood Proteins - metabolism; Bone Density Conservation Agents - chemical synthesis; Bone Density Conservation Agents - chemistry; Bone Density Conservation Agents - pharmacology; Bones, joints and connective tissue. Antiinflammatory agents; Cathepsin K; Cathepsins - antagonists & inhibitors; Cathepsins - chemistry; Cell Line; Cell Membrane Permeability; Chemistry, Medicinal; Crystallography, X-Ray; Haplorhini; Humans; Life Sciences & Biomedicine; Medical sciences; Molecular Conformation; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Protein Binding; Rats; Science & Technology; Stereoisomerism; Structure-Activity Relationship; Sulfones - chemical synthesis; Sulfones - chemistry; Sulfones - pharmacology; DESIGN; POTENT; ASSAY; CRYSTAL-STRUCTURE; BINDING; CONFORMATIONS; MOLECULES; Intravenous administration; Rat; Cysteine endopeptidases; Monkey; Non peptide compound; Clearance; Pyridine derivatives; Structure activity relation; Primates; Chemical synthesis; Cathepsin K; Sulfonamide; Enzyme; Rodentia; Oral administration; Enzyme inhibitor; Resorption; Bioavailability; In vitro; Peptidases; Vertebrata; Mammalia; Animal; Hydrolases; Carboxamide; Benzofuran derivatives; Bone; Pharmacokinetics