Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine−Poly(N-methylpyrrole) Conjugates - Wells, Geoff; Martin, Christopher R. H; Howard, Philip W; Sands, Zara A; Laughton, Charles A; Tiberghien, Arnaud; Woo, Chi Kit; Masterson, Luke A; Stephenson, Marissa J; Hartley, John A; Jenkins, Terence C; Shnyder, Steven D; et al. (Journal of medicinal chemistry, 2006)
Keywords: Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Benzodiazepines - chemical synthesis; Benzodiazepines - chemistry; Benzodiazepines - pharmacology; Biological and medical sciences; Cell Line, Tumor; Cell Membrane Permeability; Cell Nucleus - metabolism; Chemistry, Medicinal; DNA - chemistry; DNA Footprinting; Drug Screening Assays, Antitumor; Heterocyclic Compounds, 3-Ring - chemical synthesis; Heterocyclic Compounds, 3-Ring - chemistry; Heterocyclic Compounds, 3-Ring - pharmacology; Humans; Life Sciences & Biomedicine; Medical sciences; Miscellaneous; Models, Molecular; Nucleic Acid Denaturation; Permeability; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Pyrroles - chemical synthesis; Pyrroles - chemistry; Pyrroles - pharmacology; Science & Technology; Stereoisomerism; Structure-Activity Relationship; Transcription, Genetic; (PBD)-DISTAMYCIN HYBRID; DNA-BINDING AFFINITY; LINKER LENGTH; HYBRID MOLECULES; IN-VITRO CYTOTOXICITY; OLIGOPYRROLE CARRIERS; INTERSTRAND CROSS-LINKING; MINOR-GROOVE; NUCLEIC-ACIDS; DUPLEX DNA; Human; Leukemia; Footprinting technique; Pyrrole derivative polymer; Cytotoxicity; Thermal denaturation; Molecular interaction; In vitro; Modeling; Biological activity; Biological fixation; Cell line; DNA; Molecular model; Conjugated compound; Chemical synthesis; Tumor cell