Mechanobiology of Macrophages: How Physical Factors Coregulate Macrophage Plasticity and Phagocytosis

• Published in: Annual review of biomedical engineering Vol. 21; p. 267
• Main Authors: Jain, Nikhil, Moeller, Jens, Vogel, Viola
• Format: Journal Article
• Language: English
• Published: United States 04.06.2019
• Subjects: macrophage mechanics; immune cells; immunoengineering; resident macrophages; mechanotransduction; mechanotranscriptomics

In addition to their early-recognized functions in host defense and the clearance of apoptotic cell debris, macrophages play vital roles in tissue development, homeostasis, and repair. If misregulated, they steer the progression of many inflammatory diseases. Much progress has been made in understan...