Mechanobiology of Macrophages: How Physical Factors Coregulate Macrophage Plasticity and Phagocytosis
In addition to their early-recognized functions in host defense and the clearance of apoptotic cell debris, macrophages play vital roles in tissue development, homeostasis, and repair. If misregulated, they steer the progression of many inflammatory diseases. Much progress has been made in understan...
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| Published in | Annual review of biomedical engineering Vol. 21; p. 267 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
04.06.2019
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| Subjects | |
| Online Access | Get more information |
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| Abstract | In addition to their early-recognized functions in host defense and the clearance of apoptotic cell debris, macrophages play vital roles in tissue development, homeostasis, and repair. If misregulated, they steer the progression of many inflammatory diseases. Much progress has been made in understanding the mechanisms underlying macrophage signaling, transcriptomics, and proteomics, under physiological and pathological conditions. Yet, the detailed mechanisms that tune circulating monocytes/macrophages and tissue-resident macrophage polarization, differentiation, specification, and their functional plasticity remain elusive. We review how physical factors affect macrophage phenotype and function, including how they hunt for particles and pathogens, as well as the implications for phagocytosis, autophagy, and polarization from proinflammatory to prohealing phenotype. We further discuss how this knowledge can be harnessed in regenerative medicine and for the design of new drugs and immune-modulatory drug delivery systems, biomaterials, and tissue scaffolds. |
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| AbstractList | In addition to their early-recognized functions in host defense and the clearance of apoptotic cell debris, macrophages play vital roles in tissue development, homeostasis, and repair. If misregulated, they steer the progression of many inflammatory diseases. Much progress has been made in understanding the mechanisms underlying macrophage signaling, transcriptomics, and proteomics, under physiological and pathological conditions. Yet, the detailed mechanisms that tune circulating monocytes/macrophages and tissue-resident macrophage polarization, differentiation, specification, and their functional plasticity remain elusive. We review how physical factors affect macrophage phenotype and function, including how they hunt for particles and pathogens, as well as the implications for phagocytosis, autophagy, and polarization from proinflammatory to prohealing phenotype. We further discuss how this knowledge can be harnessed in regenerative medicine and for the design of new drugs and immune-modulatory drug delivery systems, biomaterials, and tissue scaffolds. |
| Author | Vogel, Viola Jain, Nikhil Moeller, Jens |
| Author_xml | – sequence: 1 givenname: Nikhil surname: Jain fullname: Jain, Nikhil email: viola.vogel@hest.ethz.ch organization: Laboratory of Applied Mechanobiology, Institute of Translational Medicine, and Department of Health Sciences and Technology, ETH Zurich, CH-8093 Zurich, Switzerland; email: viola.vogel@hest.ethz.ch – sequence: 2 givenname: Jens surname: Moeller fullname: Moeller, Jens email: viola.vogel@hest.ethz.ch organization: Laboratory of Applied Mechanobiology, Institute of Translational Medicine, and Department of Health Sciences and Technology, ETH Zurich, CH-8093 Zurich, Switzerland; email: viola.vogel@hest.ethz.ch – sequence: 3 givenname: Viola surname: Vogel fullname: Vogel, Viola email: viola.vogel@hest.ethz.ch organization: Laboratory of Applied Mechanobiology, Institute of Translational Medicine, and Department of Health Sciences and Technology, ETH Zurich, CH-8093 Zurich, Switzerland; email: viola.vogel@hest.ethz.ch |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31167103$$D View this record in MEDLINE/PubMed |
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