Critical analysis of polycyclic tetramate macrolactam biosynthetic gene cluster phylogeny and functional diversity

Polycyclic tetramate macrolactam (PTM) pathways are frequently found within the genomes of biotechnologically important bacteria, including Streptomyces and Lysobacter spp . Their molecular products are typically bioactive, having substantial agricultural and therapeutic interest. Leveraging bacteri...

Full description

Saved in:
Bibliographic Details
Published inApplied and environmental microbiology Vol. 90; no. 6; p. e0060024
Main Authors Harper, Christopher P., Day, Anna, Tsingos, Maya, Ding, Edward, Zeng, Elizabeth, Stumpf, Spencer D., Qi, Yunci, Robinson, Adam, Greif, Jennifer, Blodgett, Joshua A. V.
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 18.06.2024
Subjects
Bioinformatics
Biosynthesis
Biosynthetic Pathways - genetics
Biotechnology
Complexity
Computational Biology
Gene clusters
Genetics and Molecular Biology
Lactams - metabolism
Lysobacter - classification
Lysobacter - genetics
Lysobacter - metabolism
Metabolomics
Multigene Family
Natural products
Phylogeny
Streptomyces - classification
Streptomyces - genetics
Streptomyces - metabolism
biosynthetic gene clusters
phylogeny
comparative metabologenomics
polycyclic tetramate macrolactams
Online AccessGet full text
ISSN0099-2240
1098-5336
1098-5336
DOI10.1128/aem.00600-24

Cover

Abstract Polycyclic tetramate macrolactam (PTM) pathways are frequently found within the genomes of biotechnologically important bacteria, including Streptomyces and Lysobacter spp . Their molecular products are typically bioactive, having substantial agricultural and therapeutic interest. Leveraging bacterial genomics for the discovery of new related molecules is thus desirable, but drawing accurate structural predictions from bioinformatics alone remains challenging. This difficulty stems from a combination of previously underappreciated biosynthetic complexity and remaining knowledge gaps, compounded by a stream of yet-uncharacterized PTM biosynthetic loci gleaned from recently sequenced bacterial genomes. We engaged in the following study to create a useful framework for cataloging historic PTM clusters, identifying new cluster variations, and tracing evolutionary paths for these molecules. Our data suggest new PTM chemistry remains discoverable in nature. However, our metabolomic and mutational analyses emphasize the practical limitations of genomics-based discovery by exposing hidden complexity.
AbstractList Polycyclic tetramate macrolactams (PTMs) are bioactive natural products commonly associated with certain actinobacterial and proteobacterial lineages. These molecules have been the subject of numerous structure-activity investigations since the 1970s. New members continue to be pursued in wild and engineered bacterial strains, and advances in PTM biosynthesis suggest their outwardly simplistic biosynthetic gene clusters (BGCs) belie unexpected product complexity. To address the origins of this complexity and understand its influence on PTM discovery, we engaged in a combination of bioinformatics to systematically classify PTM BGCs and PTM-targeted metabolomics to compare the products of select BGC types. By comparing groups of producers and BGC mutants, we exposed knowledge gaps that complicate bioinformatics-driven product predictions. In sum, we provide new insights into the evolution of PTM BGCs while systematically accounting for the PTMs discovered thus far. The combined computational and metabologenomic findings presented here should prove useful for guiding future discovery.IMPORTANCEPolycyclic tetramate macrolactam (PTM) pathways are frequently found within the genomes of biotechnologically important bacteria, including Streptomyces and Lysobacter spp. Their molecular products are typically bioactive, having substantial agricultural and therapeutic interest. Leveraging bacterial genomics for the discovery of new related molecules is thus desirable, but drawing accurate structural predictions from bioinformatics alone remains challenging. This difficulty stems from a combination of previously underappreciated biosynthetic complexity and remaining knowledge gaps, compounded by a stream of yet-uncharacterized PTM biosynthetic loci gleaned from recently sequenced bacterial genomes. We engaged in the following study to create a useful framework for cataloging historic PTM clusters, identifying new cluster variations, and tracing evolutionary paths for these molecules. Our data suggest new PTM chemistry remains discoverable in nature. However, our metabolomic and mutational analyses emphasize the practical limitations of genomics-based discovery by exposing hidden complexity.
Polycyclic tetramate macrolactams (PTMs) are bioactive natural products commonly associated with certain actinobacterial and proteobacterial lineages. These molecules have been the subject of numerous structure-activity investigations since the 1970s. New members continue to be pursued in wild and engineered bacterial strains, and advances in PTM biosynthesis suggest their outwardly simplistic biosynthetic gene clusters (BGCs) belie unexpected product complexity. To address the origins of this complexity and understand its influence on PTM discovery, we engaged in a combination of bioinformatics to systematically classify PTM BGCs and PTM-targeted metabolomics to compare the products of select BGC types. By comparing groups of producers and BGC mutants, we exposed knowledge gaps that complicate bioinformatics-driven product predictions. In sum, we provide new insights into the evolution of PTM BGCs while systematically accounting for the PTMs discovered thus far. The combined computational and metabologenomic findings presented here should prove useful for guiding future discovery.IMPORTANCEPolycyclic tetramate macrolactam (PTM) pathways are frequently found within the genomes of biotechnologically important bacteria, including Streptomyces and Lysobacter spp. Their molecular products are typically bioactive, having substantial agricultural and therapeutic interest. Leveraging bacterial genomics for the discovery of new related molecules is thus desirable, but drawing accurate structural predictions from bioinformatics alone remains challenging. This difficulty stems from a combination of previously underappreciated biosynthetic complexity and remaining knowledge gaps, compounded by a stream of yet-uncharacterized PTM biosynthetic loci gleaned from recently sequenced bacterial genomes. We engaged in the following study to create a useful framework for cataloging historic PTM clusters, identifying new cluster variations, and tracing evolutionary paths for these molecules. Our data suggest new PTM chemistry remains discoverable in nature. However, our metabolomic and mutational analyses emphasize the practical limitations of genomics-based discovery by exposing hidden complexity.Polycyclic tetramate macrolactams (PTMs) are bioactive natural products commonly associated with certain actinobacterial and proteobacterial lineages. These molecules have been the subject of numerous structure-activity investigations since the 1970s. New members continue to be pursued in wild and engineered bacterial strains, and advances in PTM biosynthesis suggest their outwardly simplistic biosynthetic gene clusters (BGCs) belie unexpected product complexity. To address the origins of this complexity and understand its influence on PTM discovery, we engaged in a combination of bioinformatics to systematically classify PTM BGCs and PTM-targeted metabolomics to compare the products of select BGC types. By comparing groups of producers and BGC mutants, we exposed knowledge gaps that complicate bioinformatics-driven product predictions. In sum, we provide new insights into the evolution of PTM BGCs while systematically accounting for the PTMs discovered thus far. The combined computational and metabologenomic findings presented here should prove useful for guiding future discovery.IMPORTANCEPolycyclic tetramate macrolactam (PTM) pathways are frequently found within the genomes of biotechnologically important bacteria, including Streptomyces and Lysobacter spp. Their molecular products are typically bioactive, having substantial agricultural and therapeutic interest. Leveraging bacterial genomics for the discovery of new related molecules is thus desirable, but drawing accurate structural predictions from bioinformatics alone remains challenging. This difficulty stems from a combination of previously underappreciated biosynthetic complexity and remaining knowledge gaps, compounded by a stream of yet-uncharacterized PTM biosynthetic loci gleaned from recently sequenced bacterial genomes. We engaged in the following study to create a useful framework for cataloging historic PTM clusters, identifying new cluster variations, and tracing evolutionary paths for these molecules. Our data suggest new PTM chemistry remains discoverable in nature. However, our metabolomic and mutational analyses emphasize the practical limitations of genomics-based discovery by exposing hidden complexity.
Polycyclic tetramate macrolactam (PTM) pathways are frequently found within the genomes of biotechnologically important bacteria, including Streptomyces and Lysobacter spp . Their molecular products are typically bioactive, having substantial agricultural and therapeutic interest. Leveraging bacterial genomics for the discovery of new related molecules is thus desirable, but drawing accurate structural predictions from bioinformatics alone remains challenging. This difficulty stems from a combination of previously underappreciated biosynthetic complexity and remaining knowledge gaps, compounded by a stream of yet-uncharacterized PTM biosynthetic loci gleaned from recently sequenced bacterial genomes. We engaged in the following study to create a useful framework for cataloging historic PTM clusters, identifying new cluster variations, and tracing evolutionary paths for these molecules. Our data suggest new PTM chemistry remains discoverable in nature. However, our metabolomic and mutational analyses emphasize the practical limitations of genomics-based discovery by exposing hidden complexity.
Polycyclic tetramate macrolactams (PTMs) are bioactive natural products commonly associated with certain actinobacterial and proteobacterial lineages. These molecules have been the subject of numerous structure-activity investigations since the 1970s. New members continue to be pursued in wild and engineered bacterial strains, and advances in PTM biosynthesis suggest their outwardly simplistic biosynthetic gene clusters (BGCs) belie unexpected product complexity. To address the origins of this complexity and understand its influence on PTM discovery, we engaged in a combination of bioinformatics to systematically classify PTM BGCs and PTM-targeted metabolomics to compare the products of select BGC types. By comparing groups of producers and BGC mutants, we exposed knowledge gaps that complicate bioinformatics-driven product predictions. In sum, we provide new insights into the evolution of PTM BGCs while systematically accounting for the PTMs discovered thus far. The combined computational and metabologenomic findings presented here should prove useful for guiding future discovery. Polycyclic tetramate macrolactam (PTM) pathways are frequently found within the genomes of biotechnologically important bacteria, including and spp Their molecular products are typically bioactive, having substantial agricultural and therapeutic interest. Leveraging bacterial genomics for the discovery of new related molecules is thus desirable, but drawing accurate structural predictions from bioinformatics alone remains challenging. This difficulty stems from a combination of previously underappreciated biosynthetic complexity and remaining knowledge gaps, compounded by a stream of yet-uncharacterized PTM biosynthetic loci gleaned from recently sequenced bacterial genomes. We engaged in the following study to create a useful framework for cataloging historic PTM clusters, identifying new cluster variations, and tracing evolutionary paths for these molecules. Our data suggest new PTM chemistry remains discoverable in nature. However, our metabolomic and mutational analyses emphasize the practical limitations of genomics-based discovery by exposing hidden complexity.
Polycyclic tetramate macrolactams (PTMs) are bioactive natural products commonly associated with certain actinobacterial and proteobacterial lineages. These molecules have been the subject of numerous structure-activity investigations since the 1970s. New members continue to be pursued in wild and engineered bacterial strains, and advances in PTM biosynthesis suggest their outwardly simplistic biosynthetic gene clusters (BGCs) belie unexpected product complexity. To address the origins of this complexity and understand its influence on PTM discovery, we engaged in a combination of bioinformatics to systematically classify PTM BGCs and PTM-targeted metabolomics to compare the products of select BGC types. By comparing groups of producers and BGC mutants, we exposed knowledge gaps that complicate bioinformatics-driven product predictions. In sum, we provide new insights into the evolution of PTM BGCs while systematically accounting for the PTMs discovered thus far. The combined computational and metabologenomic findings presented here should prove useful for guiding future discovery.
Author Qi, Yunci
Zeng, Elizabeth
Robinson, Adam
Harper, Christopher P.
Day, Anna
Greif, Jennifer
Ding, Edward
Tsingos, Maya
Stumpf, Spencer D.
Blodgett, Joshua A. V.
Author_xml – sequence: 1
  givenname: Christopher P.
  orcidid: 0000-0002-4079-519X
  surname: Harper
  fullname: Harper, Christopher P.
  organization: Department of Biology, Washington University in St. Louis, St. Louis, Missouri, USA
– sequence: 2
  givenname: Anna
  surname: Day
  fullname: Day, Anna
  organization: Department of Biology, Washington University in St. Louis, St. Louis, Missouri, USA
– sequence: 3
  givenname: Maya
  surname: Tsingos
  fullname: Tsingos, Maya
  organization: Department of Biology, Washington University in St. Louis, St. Louis, Missouri, USA
– sequence: 4
  givenname: Edward
  surname: Ding
  fullname: Ding, Edward
  organization: Department of Biology, Washington University in St. Louis, St. Louis, Missouri, USA
– sequence: 5
  givenname: Elizabeth
  surname: Zeng
  fullname: Zeng, Elizabeth
  organization: Department of Biology, Washington University in St. Louis, St. Louis, Missouri, USA
– sequence: 6
  givenname: Spencer D.
  surname: Stumpf
  fullname: Stumpf, Spencer D.
  organization: Department of Biology, Washington University in St. Louis, St. Louis, Missouri, USA
– sequence: 7
  givenname: Yunci
  surname: Qi
  fullname: Qi, Yunci
  organization: Department of Biology, Washington University in St. Louis, St. Louis, Missouri, USA
– sequence: 8
  givenname: Adam
  surname: Robinson
  fullname: Robinson, Adam
  organization: Department of Biology, Washington University in St. Louis, St. Louis, Missouri, USA
– sequence: 9
  givenname: Jennifer
  surname: Greif
  fullname: Greif, Jennifer
  organization: Department of Biology, Washington University in St. Louis, St. Louis, Missouri, USA
– sequence: 10
  givenname: Joshua A. V.
  orcidid: 0000-0002-7080-5870
  surname: Blodgett
  fullname: Blodgett, Joshua A. V.
  organization: Department of Biology, Washington University in St. Louis, St. Louis, Missouri, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38771054$$D View this record in MEDLINE/PubMed
BookMark eNp1kctv1DAQhy1URNuFG2dkiQtIpEycl32q0IqXVIkLnK2JM-m6cuLFdirlv8fLtjwqOFmyv_k8M79zdjL7mRh7XsJFWQr5Fmm6AGgBClE_YmclKFk0VdWesDMApQohajhl5zHeAEANrXzCTivZdSU09RkL22CTNeg4zujWaCP3I997t5rVOGt4ohRwwkR8QhO8Q5Nw4r31cZ3TjnItv6aZuHFLTBT4frc6n2_WLBz4uMwmWZ_VfLC3FKJN61P2eEQX6dnduWHfPrz_uv1UXH35-Hn77qrAuu5S0ZSoWjQGytGoZkBV9Z2SBkXVy1qoVva9lFI0gzQj4NgqRQMZIgEGG1OpasMuj9790k80GJrzJE7vg50wrNqj1X-_zHanr_2tzmstZZt3uGGv7gzBf18oJj3ZaMg5nMkvUVfQdK2q6qbO6MsH6I1fQp77QHUAQkk4tPT6SGGcxG-ihMOfUuco9c8otTgYX_zZ_q--77PLgDgCOZYYA43a2ISHbedprPuf9c2DonvvP_Efv1S-iA
CitedBy_id crossref_primary_10_1002_ange_202420335
crossref_primary_10_1002_bit_28919
crossref_primary_10_1002_anie_202420335
crossref_primary_10_3390_org5040019
crossref_primary_10_1186_s12934_024_02630_8
crossref_primary_10_1007_s00253_025_13427_z
Cites_doi 10.1046/j.1365-2958.2000.01718.x
10.1021/acssynbio.1c00178
10.1007/s10295-018-2085-6
10.1007/s10482-016-0824-0
10.1101/2023.02.06.527410
10.3390/md19080440
10.1021/acssynbio.7b00349
10.1021/np990144v
10.1177/1934578X1701200818
10.1093/gbe/evq013
10.1094/PBIOMES-04-20-0032-RVW
10.1021/acs.jnatprod.5b00099
10.1007/s10482-020-01465-8
10.1094/MPMI-06-20-0164-R
10.1128/AEM.02828-17
10.1039/c9np00048h
10.1038/ncomms3894
10.1038/srep40689
10.1073/pnas.2103515118
10.3389/fmicb.2018.01959
10.1128/jb.00485-22
10.7164/antibiotics.49.1101
10.1038/s41429-018-0040-4
10.1021/ol1020064
10.1016/S0076-6879(09)04808-3
10.1515/HC.1996.2.4.315
10.1099/ijs.0.058107-0
10.3390/md20010021
10.6023/cjoc201703048
10.1128/spectrum.00571-21
10.1111/1462-2920.12388
10.1039/C9MD00154A
10.1371/journal.pone.0247348
10.1093/nar/gkz310
10.1111/1751-7915.12716
10.1021/acs.jnatprod.1c01110
10.1002/anie.201402078
10.1016/S0040-4039(00)77493-4
10.1073/pnas.2217383120
10.1038/s41396-022-01242-7
10.1038/nchembio.1366
10.3390/metabo11040239
10.1016/j.ympev.2016.08.006
10.1099/ijs.0.012419-0
10.1128/MRA.01066-20
10.1021/acs.biochem.9b00280
10.7164/antibiotics.50.1014
10.3389/fsufs.2021.643225
10.1021/acscatal.2c05784
10.1021/acs.analchem.2c02245
10.1093/bioinformatics/btr659
10.1038/s41598-017-10316-y
10.1002/anie.201310641
10.1021/acs.orglett.2c02396
10.1002/cbic.201500261
10.1093/nar/gkp377
10.1002/anie.201802488
10.1099/ijs.0.028514-0
10.1111/1751-7915.12116
10.1038/s42003-023-05230-1
10.2174/1568026616666151012112818
10.1128/jb.173.2.697-703.1991
10.1021/jo00041a053
10.7164/antibiotics.25.271
10.1021/acs.jnatprod.0c00900
10.1128/AEM.65.10.4334-4339.1999
10.1128/mBio.02700-21
10.1002/anie.201805673
10.1021/ja303004g
10.1021/acs.orglett.8b01285
10.1093/bioinformatics/btab007
10.3390/microorganisms8040583
10.1021/acs.biochem.2c00575
10.1128/AAC.00931-06
10.1073/pnas.1001513107
10.3389/fmicb.2017.02305
10.1021/acs.analchem.2c04632
10.1094/MPMI-03-11-0073
10.1039/C5CC00843C
10.1039/c6sc03875a
10.3389/fchem.2021.772858
10.1016/j.bioorg.2020.103954
10.1002/anie.201611063
10.1099/mic.0.000572
10.1186/s40168-021-01016-x
10.7554/eLife.65091
10.1371/journal.pone.0039550
10.1128/AEM.02925-14
10.1096/fj.201901237R
10.1099/ijsem.0.005225
10.1073/pnas.2006560117
10.1021/cb500432j
10.1021/acs.jnatprod.1c00606
10.1099/ijs.0.65224-0
10.1128/genomeA.01401-17
10.3390/md17120663
10.1016/j.biortech.2018.10.085
10.1073/pnas.1520289113
10.1128/AEM.01169-17
10.1016/j.syapm.2013.03.010
10.1021/acs.orglett.9b04672
10.3390/md12020999
10.1016/j.tet.2018.10.007
ContentType Journal Article
Copyright Copyright © 2024 American Society for Microbiology.
Copyright American Society for Microbiology Jun 2024
Copyright © 2024 American Society for Microbiology. 2024 American Society for Microbiology.
Copyright_xml – notice: Copyright © 2024 American Society for Microbiology.
– notice: Copyright American Society for Microbiology Jun 2024
– notice: Copyright © 2024 American Society for Microbiology. 2024 American Society for Microbiology.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7QL
7QO
7SN
7SS
7ST
7T7
7TM
7U9
8FD
C1K
FR3
H94
M7N
P64
RC3
SOI
7X8
5PM
DOI 10.1128/aem.00600-24
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Bacteriology Abstracts (Microbiology B)
Biotechnology Research Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Technology Research Database
Environmental Sciences and Pollution Management
Engineering Research Database
AIDS and Cancer Research Abstracts
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Virology and AIDS Abstracts
Technology Research Database
Nucleic Acids Abstracts
Ecology Abstracts
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
Entomology Abstracts
Genetics Abstracts
Biotechnology Research Abstracts
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
AIDS and Cancer Research Abstracts
Engineering Research Database
Industrial and Applied Microbiology Abstracts (Microbiology A)
Environment Abstracts
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
CrossRef
MEDLINE
Virology and AIDS Abstracts
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Economics
Engineering
Biology
EISSN 1098-5336
Editor Reguera, Gemma
Editor_xml – sequence: 1
  givenname: Gemma
  surname: Reguera
  fullname: Reguera, Gemma
ExternalDocumentID PMC11218653
00600-24
38771054
10_1128_aem_00600_24
Genre Research Support, U.S. Gov't, Non-P.H.S
Journal Article
GrantInformation_xml – fundername: National Science Foundation (NSF)
  grantid: 1846005
– fundername: ;
  grantid: 1846005
GroupedDBID ---
-~X
0R~
23M
2WC
39C
4.4
53G
5GY
5RE
5VS
6J9
85S
AAGFI
AAYXX
AAZTW
ABOGM
ABPPZ
ACBTR
ACGFO
ACIWK
ACNCT
ACPRK
ADBBV
ADUKH
AENEX
AFRAH
AGVNZ
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BKOMP
BTFSW
CITATION
CS3
D0L
DIK
E.-
E3Z
EBS
F5P
GX1
H13
HYE
HZ~
K-O
KQ8
L7B
O9-
P2P
PQQKQ
RHI
RNS
RPM
RSF
RXW
TAE
TN5
TR2
TWZ
UHB
W8F
WH7
WOQ
X6Y
~02
~KM
CGR
CUY
CVF
ECM
EIF
NPM
RHF
UCJ
Z5M
ZA5
7QL
7QO
7SN
7SS
7ST
7T7
7TM
7U9
8FD
C1K
FR3
H94
M7N
P64
RC3
SOI
7X8
5PM
ID FETCH-LOGICAL-a447t-51a96acc01fc95da93b798ca23b842968bb88825d8cf0af699edecee20ca5c393
ISSN 0099-2240
1098-5336
IngestDate Thu Aug 21 18:33:00 EDT 2025
Fri Jul 11 01:01:34 EDT 2025
Mon Jun 30 08:13:16 EDT 2025
Tue Jun 25 17:12:33 EDT 2024
Wed Feb 19 02:17:28 EST 2025
Thu Apr 24 23:00:19 EDT 2025
Tue Jul 01 04:29:34 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6
Keywords biosynthetic gene clusters
phylogeny
comparative metabologenomics
polycyclic tetramate macrolactams
Language English
License All Rights Reserved. https://doi.org/10.1128/ASMCopyrightv2
All Rights Reserved.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-a447t-51a96acc01fc95da93b798ca23b842968bb88825d8cf0af699edecee20ca5c393
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Present address: USDA-ARS, New Orleans, Louisiana, USA
Present address: Pfizer Inc, Chesterfield, Missouri, USA
The authors declare no conflict of interest.
Present address: Tulane School of Medicine, New Orleans, Louisiana, USA
Present address: Columbia University School of Dental Medicine, New York, New York, USA
Christopher P. Harper and Anna Day contributed equally to this article. Author order was determined on the basis of seniority.
ORCID 0000-0002-4079-519X
0000-0002-7080-5870
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/11218653
PMID 38771054
PQID 3070029809
PQPubID 42251
PageCount 21
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_11218653
proquest_miscellaneous_3057693454
proquest_journals_3070029809
asm2_journals_10_1128_aem_00600_24
pubmed_primary_38771054
crossref_citationtrail_10_1128_aem_00600_24
crossref_primary_10_1128_aem_00600_24
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2024-06-18
PublicationDateYYYYMMDD 2024-06-18
PublicationDate_xml – month: 06
  year: 2024
  text: 2024-06-18
  day: 18
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: 1752 N St., N.W., Washington, DC
– name: Washington
PublicationTitle Applied and environmental microbiology
PublicationTitleAbbrev Appl Environ Microbiol
PublicationTitleAlternate Appl Environ Microbiol
PublicationYear 2024
Publisher American Society for Microbiology
Publisher_xml – name: American Society for Microbiology
References e_1_3_5_100_2
e_1_3_5_27_2
e_1_3_5_23_2
e_1_3_5_65_2
e_1_3_5_46_2
e_1_3_5_88_2
e_1_3_5_104_2
e_1_3_5_69_2
e_1_3_5_80_2
e_1_3_5_61_2
e_1_3_5_42_2
e_1_3_5_84_2
e_1_3_5_9_2
e_1_3_5_5_2
e_1_3_5_39_2
e_1_3_5_16_2
e_1_3_5_12_2
e_1_3_5_35_2
e_1_3_5_54_2
e_1_3_5_77_2
e_1_3_5_58_2
e_1_3_5_92_2
e_1_3_5_50_2
e_1_3_5_73_2
e_1_3_5_96_2
e_1_3_5_31_2
e_1_3_5_28_2
e_1_3_5_101_2
e_1_3_5_24_2
e_1_3_5_43_2
e_1_3_5_66_2
e_1_3_5_89_2
e_1_3_5_47_2
e_1_3_5_105_2
e_1_3_5_81_2
e_1_3_5_62_2
e_1_3_5_85_2
e_1_3_5_8_2
e_1_3_5_20_2
e_1_3_5_4_2
e_1_3_5_17_2
e_1_3_5_36_2
e_1_3_5_13_2
e_1_3_5_32_2
e_1_3_5_55_2
e_1_3_5_78_2
e_1_3_5_59_2
e_1_3_5_93_2
e_1_3_5_70_2
e_1_3_5_51_2
e_1_3_5_97_2
e_1_3_5_74_2
e_1_3_5_25_2
e_1_3_5_21_2
e_1_3_5_44_2
e_1_3_5_67_2
e_1_3_5_48_2
e_1_3_5_102_2
e_1_3_5_29_2
e_1_3_5_82_2
e_1_3_5_40_2
e_1_3_5_86_2
e_1_3_5_63_2
e_1_3_5_7_2
e_1_3_5_3_2
(e_1_3_5_99_2) 2012
e_1_3_5_37_2
e_1_3_5_14_2
e_1_3_5_10_2
e_1_3_5_33_2
e_1_3_5_56_2
e_1_3_5_79_2
e_1_3_5_98_2
e_1_3_5_18_2
e_1_3_5_71_2
e_1_3_5_90_2
e_1_3_5_52_2
e_1_3_5_75_2
e_1_3_5_94_2
e_1_3_5_26_2
e_1_3_5_22_2
e_1_3_5_45_2
e_1_3_5_68_2
e_1_3_5_87_2
e_1_3_5_49_2
e_1_3_5_103_2
e_1_3_5_2_2
e_1_3_5_60_2
e_1_3_5_41_2
e_1_3_5_64_2
e_1_3_5_83_2
e_1_3_5_6_2
e_1_3_5_38_2
e_1_3_5_15_2
e_1_3_5_34_2
e_1_3_5_11_2
e_1_3_5_76_2
e_1_3_5_57_2
e_1_3_5_19_2
e_1_3_5_91_2
e_1_3_5_72_2
e_1_3_5_53_2
e_1_3_5_95_2
e_1_3_5_30_2
(B98) 2012
Li, X, Wang, H, Shen, Y, Li, Y, Du, L (B39) 2019; 58
Guan, D, Grau, BL, Clark, CA, Taylor, CM, Loria, R, Pettis, GS (B56) 2012; 25
Chevrette, MG, Gutiérrez-García, K, Selem-Mojica, N, Aguilar-Martínez, C, Yañez-Olvera, A, Ramos-Aboites, HE, Hoskisson, PA, Barona-Gómez, F (B71) 2020; 37
Armijos-Jaramillo, V, Santander-Gordón, D, Soria, R, Pazmiño-Betancourth, M, Echeverría, MC (B59) 2017; 114
Wilbanks, EG, Doré, H, Ashby, MH, Heiner, C, Roberts, RJ, Eisen, JA (B45) 2022; 16
Weisberg, AJ, Kramer, CG, Kotha, RR, Luthria, DL, Chang, JH, Clarke, CR (B101) 2021; 34
Rong, X, Huang, Y (B96) 2010; 60
Olano, C, García, I, González, A, Rodriguez, M, Rozas, D, Rubio, J, Sánchez-Hidalgo, M, Braña, AF, Méndez, C, Salas, JA (B31) 2014; 7
Jakobi, M, Winkelmann, G, Kaiser, D, Kempler, C, Jung, G, Berg, G, Bahl, H (B62) 1996; 49
Mei, X, Wang, L, Wang, D, Fan, J, Zhu, W (B7) 2017; 37
Bown, L, Hirota, R, Goettge, MN, Cui, J, Krist, DT, Zhu, L, Giurgiu, C, van der Donk, WA, Ju, K-S, Metcalf, WW (B58) 2023; 205
Davis, EW, Okrent, RA, Manning, VA, Trippe, KM (B94) 2021; 16
Blodgett, JAV, Oh, D-C, Cao, S, Currie, CR, Kolter, R, Clardy, J (B2) 2010; 107
Medema, MH, Trefzer, A, Kovalchuk, A, van den Berg, M, Müller, U, Heijne, W, Wu, L, Alam, MT, Ronning, CM, Nierman, WC, Bovenberg, RAL, Breitling, R, Takano, E (B73) 2010; 2
Ueoka, R, Bhushan, A, Probst, SI, Bray, WM, Lokey, RS, Linington, RG, Piel, J (B13) 2018; 57
Kyeremeh, K, Acquah, KS, Sazak, A, Houssen, W, Tabudravu, J, Deng, H, Jaspars, M (B9) 2014; 12
Avalon, NE, Murray, AE, Baker, BJ (B77) 2022; 94
Li, H, Zhang, Q, Li, S, Zhu, Y, Zhang, G, Zhang, H, Tian, X, Zhang, S, Ju, J, Zhang, C (B69) 2012; 134
Moree, WJ, McConnell, OJ, Nguyen, DD, Sanchez, LM, Yang, Y-L, Zhao, X, Liu, W-T, Boudreau, PD, Srinivasan, J, Atencio, L, Ballesteros, J, Gavilán, RG, Torres-Mendoza, D, Guzmán, HM, Gerwick, WH, Gutiérrez, M, Dorrestein, PC (B12) 2014; 9
Rong, X, Doroghazi, JR, Cheng, K, Zhang, L, Buckley, DH, Huang, Y (B102) 2013; 36
Yan, Y, Wang, H, Song, Y, Zhu, D, Shen, Y, Li, Y (B22) 2021; 10
Liu, W, Zhang, W, Jin, H, Zhang, Q, Chen, Y, Jiang, X, Zhang, G, Zhang, L, Zhang, W, She, Z, Zhang, C (B23) 2019; 17
Hoshino, S, Wong, CP, Ozeki, M, Zhang, H, Hayashi, F, Awakawa, T, Asamizu, S, Onaka, H, Abe, I (B11) 2018; 71
Greunke, C, Antosch, J, Gulder, TAM (B14) 2015; 51
Labeda, DP (B97) 2011; 61
Nakayama, T, Homma, Y, Hashidoko, Y, Mizutani, J, Tahara, S (B65) 1999; 65
Bae, M-A, Yamada, K, Ijuin, Y, Tsuji, T, Yazawa, K, Uemura, D (B61) 1996; 2
Prieto, C, García-Estrada, C, Lorenzana, D, Martín, JF (B90) 2012; 28
Fukuda, T, Takahashi, M, Kasai, H, Nagai, K, Tomoda, H (B25) 2017; 12
Weisburg, WG, Barns, SM, Pelletier, DA, Lane, DJ (B104) 1991; 173
Greunke, C, Glöckle, A, Antosch, J, Gulder, TAM (B8) 2017; 56
Guo, Y, Zheng, W, Rong, X, Huang, Y (B95) 2008; 58
Armin, R, Zühlke, S, Mahnkopp-Dirks, F, Winkelmann, T, Kusari, S (B85) 2021; 5
Vior, NM, Lacret, R, Chandra, G, Dorai-Raj, S, Trick, M, Truman, AW (B3) 2018; 84
Claverys, JP, Prudhomme, M, Mortier-Barrière, I, Martin, B (B52) 2000; 35
Graupner, PR, Thornburgh, S, Mathieson, JT, Chapin, EL, Kemmitt, GM, Brown, JM, Snipes, CE (B64) 1997; 50
Contreras-Moreira, B, Sachman-Ruiz, B, Figueroa-Palacios, I, Vinuesa, P (B103) 2009; 37
Bown, L, Li, Y, Berrué, F, Verhoeven, JTP, Dufour, SC, Bignell, DRD (B4) 2017; 83
Shigdel, UK, Lee, S-J, Sowa, ME, Bowman, BR, Robison, K, Zhou, M, Pua, KH, Stiles, DT, Blodgett, JAV, Udwary, DW (B72) 2020; 117
Jomon, K, Kuroda, Y, Ajisaka, M, Sakai, H (B28) 1972; 25
Li, X, Liu, Q, Zou, H, Luo, J, Jiao, Y, Wang, H, Du, L, Shen, Y, Li, Y (B48) 2023; 13
Ahmed, Y, Rebets, Y, Tokovenko, B, Brötz, E, Luzhetskyy, A (B67) 2017; 7
Zou, H, Xia, X, Xu, Q, Wang, H, Shen, Y, Li, Y (B10) 2022; 24
Li, Y, Wang, H, Liu, Y, Jiao, Y, Li, S, Shen, Y, Du, L (B15) 2018; 57
Lin, Y, Wang, L, Xu, K, Li, K, Ren, H (B47) 2021; 9
Ding, L, Zhang, S-D, Haidar, AK, Bajimaya, M, Guo, Y, Larsen, TO, Gram, L (B68) 2021; 9
Deutsch, JM, Mandelare-Ruiz, P, Yang, Y, Foster, G, Routhu, A, Houk, J, De La Flor, YT, Ushijima, B, Meyer, JL, Paul, VJ, Garg, N (B87) 2022; 85
Nguyen, HP, Weisberg, AJ, Chang, JH, Clarke, CR (B54) 2022; 72
Zhang, Y, Xu, J, Wang, E, Wang, N (B43) 2020; 8
Labeda, DP, Doroghazi, JR, Ju, K-S, Metcalf, WW (B99) 2014; 64
Qi, Y, Ding, E, Blodgett, JAV (B6) 2018; 7
Cao, S, Blodgett, JAV, Clardy, J (B33) 2010; 12
Shaikh, AA, Nothias, L-F, Srivastava, SK, Dorrestein, PC, Tahlan, K (B86) 2021; 11
Jiao, Y-J, Liu, Y, Wang, H-X, Zhu, D-Y, Shen, Y-M, Li, Y-Y (B5) 2020; 83
Joynt, R, Seipke, RF (B49) 2018; 164
Ding, W, Tu, J, Zhang, H, Wei, X, Ju, J, Li, Q (B21) 2021; 19
Zhang, G, Zhang, W, Zhang, Q, Shi, T, Ma, L, Zhu, Y, Li, S, Zhang, H, Zhao, Y-L, Shi, R, Zhang, C (B34) 2014; 53
Gilchrist, CLM, Chooi, Y-H (B92) 2021; 37
Liu, Y, Wang, H, Song, R, Chen, J, Li, T, Li, Y, Du, L, Shen, Y (B30) 2018; 20
Cheng, K, Rong, X, Pinto-Tomás, AA, Fernández-Villalobos, M, Murillo-Cruz, C, Huang, Y (B100) 2015; 81
Tang, B, Laborda, P, Sun, C, Xu, G, Zhao, Y, Liu, F (B63) 2019; 273
Mannochio-Russo, H, Swift, SOI, Nakayama, KK, Wall, CB, Gentry, EC, Panitchpakdi, M, Caraballo-Rodriguez, AM, Aron, AT, Petras, D, Dorrestein, K (B79) 2023; 6
Kosmopoulos, JC, Campbell, DE, Whitaker, RJ, Wilbanks, EG (B46) 2023; 89
Li, X, Wang, H, Li, Y, Du, L (B35) 2019; 10
Jiang, S-H, Dong, F-Y, Da, L-T, Yang, X-M, Wang, X-X, Weng, J-Y, Feng, L, Zhu, L-L, Zhang, Y-L, Zhang, Z-G, Sun, Y-W, Li, J, Xu, M-J (B29) 2020; 34
Blin, K, Shaw, S, Steinke, K, Villebro, R, Ziemert, N, Lee, SY, Medema, MH, Weber, T (B89) 2019; 47
Pessotti, R de C, Hansen, BL, Reaso, JN, Ceja-Navarro, JA, El-Hifnawi, L, Brodie, EL, Traxler, MF (B82) 2021; 10
Chevrette, MG, Currie, CR (B70) 2019; 46
Paulus, C, Rebets, Y, Zapp, J, Rückert, C, Kalinowski, J, Luzhetskyy, A (B84) 2018; 9
Qi, Y, Nepal, KK, Blodgett, JAV (B38) 2021; 118
Zhang, W, Zhang, G, Zhang, L, Liu, W, Jiang, X, Jin, H, Liu, Z, Zhang, H, Zhou, A, Zhang, C (B37) 2018; 74
Saha, S, Zhang, W, Zhang, G, Zhu, Y, Chen, Y, Liu, W, Yuan, C, Zhang, Q, Zhang, H, Zhang, L, Zhang, W, Zhang, C (B18) 2017; 8
Schaub, P, Yu, Q, Gemmecker, S, Poussin-Courmontagne, P, Mailliot, J, McEwen, AG, Ghisla, S, Al-Babili, S, Cavarelli, J, Beyer, P (B51) 2012; 7
Qi, Y, Nepal, KK, Greif, J, Martini, C, Tomlinson, C, Markovic, C, Fronick, C, Blodgett, JAV (B88) 2020; 9
Samples, RM, Puckett, SP, Balunas, MJ (B81) 2023; 95
Yu, H-L, Jiang, S-H, Bu, X-L, Wang, J-H, Weng, J-Y, Yang, X-M, He, K-Y, Zhang, Z-G, Ao, P, Xu, J, Xu, M-J (B26) 2017; 7
Tsunematsu, Y, Ishikawa, N, Wakana, D, Goda, Y, Noguchi, H, Moriya, H, Hotta, K, Watanabe, K (B75) 2013; 9
Cano-Prieto, C, Losada, AA, Braña, AF, Méndez, C, Salas, JA, Olano, C (B76) 2015; 16
Planckaert, S, Deflandre, B, de Vries, A-M, Ameye, M, Martins, JC, Audenaert, K, Rigali, S, Devreese, B (B57) 2021; 9
Capon, RJ, Skene, C, Lacey, E, Gill, JH, Wadsworth, D, Friedel, T (B42) 1999; 62
Hou, L, Liu, Z, Yu, D, Li, H, Ju, J, Li, W (B19) 2020; 101
Aharoni, A, Goodacre, R, Fernie, AR (B80) 2023; 120
Shigemori, H, Bae, MA, Yazawa, K, Sasaki, T, Kobayashi, J (B60) 1992; 57
Luo, J, Li, X, Wang, H, Du, L, Shen, Y, Li, Y (B40) 2022; 61
Yang, J, Qi, Y, Blodgett, JAV, Wencewicz, TA (B20) 2022; 85
Labeda, DP, Dunlap, CA, Rong, X, Huang, Y, Doroghazi, JR, Ju, K-S, Metcalf, WW (B93) 2017; 110
Antosch, J, Schaefers, F, Gulder, TAM (B16) 2014; 53
Pinto-Almeida, A, Bauermeister, A, Luppino, L, Grilo, IR, Oliveira, J, Sousa, JR, Petras, D, Rodrigues, CF, Prieto-Davó, A, Tasdemir, D, Sobral, RG, Gaudêncio, SP (B83) 2021; 20
Chase, AB, Sweeney, D, Muskat, MN, Guillén-Matus, DG, Jensen, PR (B50) 2021; 12
Wilbanks, EG, Jaekel, U, Salman, V, Humphrey, PT, Eisen, JA, Facciotti, MT, Buckley, DH, Zinder, SH, Druschel, GK, Fike, DA, Orphan, VJ (B44) 2014; 16
Kellogg, J, Kang, S (B78) 2020; 4
Yu, F, Zaleta-Rivera, K, Zhu, X, Huffman, J, Millet, JC, Harris, SD, Yuen, G, Li, X-C, Du, L (B1) 2007; 51
Quezada, M, Licona-Cassani, C, Cruz-Morales, P, Salim, AA, Marcellin, E, Capon, RJ, Barona-Gómez, F (B66) 2017; 8
Losada, AA, Cano-Prieto, C, García-Salcedo, R, Braña, AF, Méndez, C, Salas, JA, Olano, C (B74) 2017; 10
Jin, H, Zhang, W, Zhang, G, Zhang, L, Liu, W, Zhang, C (B24) 2020; 22
Bachmann, BO, Ravel, J (B91) 2009
Malcomson, B, Wilson, H, Veglia, E, Thillaiyampalam, G, Barsden, R, Donegan, S, El Banna, A, Elborn, JS, Ennis, M, Kelly, C, Zhang, S-D, Schock, BC (B27) 2016; 113
Gu, L, Zhang, K, Zhang, N, Li, X, Liu, Z (B53) 2020; 113
Xu, L, Wu, P, Wright, SJ, Du, L, Wei, X (B36) 2015; 78
Kanazawa, S, Fusetani, N, Matsunaga, S (B41) 1993; 34
Qi, Y, D’Alessandro, JM, Blodgett, JAV (B55) 2018; 6
Zhang, G, Zhang, W, Saha, S, Zhang, C (B17) 2016; 16
Luo, Y, Huang, H, Liang, J, Wang, M, Lu, L, Shao, Z, Cobb, RE, Zhao, H (B32) 2013; 4
References_xml – ident: e_1_3_5_53_2
  doi: 10.1046/j.1365-2958.2000.01718.x
– ident: e_1_3_5_23_2
  doi: 10.1021/acssynbio.1c00178
– ident: e_1_3_5_71_2
  doi: 10.1007/s10295-018-2085-6
– ident: e_1_3_5_94_2
  doi: 10.1007/s10482-016-0824-0
– ident: e_1_3_5_47_2
  doi: 10.1101/2023.02.06.527410
– ident: e_1_3_5_22_2
  doi: 10.3390/md19080440
– ident: e_1_3_5_7_2
  doi: 10.1021/acssynbio.7b00349
– ident: e_1_3_5_43_2
  doi: 10.1021/np990144v
– ident: e_1_3_5_26_2
  doi: 10.1177/1934578X1701200818
– ident: e_1_3_5_74_2
  doi: 10.1093/gbe/evq013
– ident: e_1_3_5_79_2
  doi: 10.1094/PBIOMES-04-20-0032-RVW
– ident: e_1_3_5_37_2
  doi: 10.1021/acs.jnatprod.5b00099
– ident: e_1_3_5_54_2
  doi: 10.1007/s10482-020-01465-8
– ident: e_1_3_5_102_2
  doi: 10.1094/MPMI-06-20-0164-R
– volume-title: Bergey’s manual of systematic bacteriology
  year: 2012
  ident: e_1_3_5_99_2
– ident: e_1_3_5_4_2
  doi: 10.1128/AEM.02828-17
– ident: e_1_3_5_72_2
  doi: 10.1039/c9np00048h
– ident: e_1_3_5_33_2
  doi: 10.1038/ncomms3894
– ident: e_1_3_5_27_2
  doi: 10.1038/srep40689
– ident: e_1_3_5_39_2
  doi: 10.1073/pnas.2103515118
– ident: e_1_3_5_85_2
  doi: 10.3389/fmicb.2018.01959
– ident: e_1_3_5_59_2
  doi: 10.1128/jb.00485-22
– ident: e_1_3_5_63_2
  doi: 10.7164/antibiotics.49.1101
– ident: e_1_3_5_12_2
  doi: 10.1038/s41429-018-0040-4
– ident: e_1_3_5_34_2
  doi: 10.1021/ol1020064
– ident: e_1_3_5_92_2
  doi: 10.1016/S0076-6879(09)04808-3
– ident: e_1_3_5_62_2
  doi: 10.1515/HC.1996.2.4.315
– ident: e_1_3_5_100_2
  doi: 10.1099/ijs.0.058107-0
– ident: e_1_3_5_84_2
  doi: 10.3390/md20010021
– ident: e_1_3_5_8_2
  doi: 10.6023/cjoc201703048
– ident: e_1_3_5_58_2
  doi: 10.1128/spectrum.00571-21
– ident: e_1_3_5_45_2
  doi: 10.1111/1462-2920.12388
– ident: e_1_3_5_36_2
  doi: 10.1039/C9MD00154A
– ident: e_1_3_5_95_2
  doi: 10.1371/journal.pone.0247348
– ident: e_1_3_5_90_2
  doi: 10.1093/nar/gkz310
– ident: e_1_3_5_75_2
  doi: 10.1111/1751-7915.12716
– ident: e_1_3_5_88_2
  doi: 10.1021/acs.jnatprod.1c01110
– ident: e_1_3_5_35_2
  doi: 10.1002/anie.201402078
– ident: e_1_3_5_42_2
  doi: 10.1016/S0040-4039(00)77493-4
– ident: e_1_3_5_81_2
  doi: 10.1073/pnas.2217383120
– ident: e_1_3_5_46_2
  doi: 10.1038/s41396-022-01242-7
– ident: e_1_3_5_76_2
  doi: 10.1038/nchembio.1366
– ident: e_1_3_5_87_2
  doi: 10.3390/metabo11040239
– ident: e_1_3_5_60_2
  doi: 10.1016/j.ympev.2016.08.006
– ident: e_1_3_5_97_2
  doi: 10.1099/ijs.0.012419-0
– ident: e_1_3_5_89_2
  doi: 10.1128/MRA.01066-20
– ident: e_1_3_5_40_2
  doi: 10.1021/acs.biochem.9b00280
– ident: e_1_3_5_65_2
  doi: 10.7164/antibiotics.50.1014
– ident: e_1_3_5_86_2
  doi: 10.3389/fsufs.2021.643225
– ident: e_1_3_5_49_2
  doi: 10.1021/acscatal.2c05784
– ident: e_1_3_5_78_2
  doi: 10.1021/acs.analchem.2c02245
– ident: e_1_3_5_91_2
  doi: 10.1093/bioinformatics/btr659
– ident: e_1_3_5_68_2
  doi: 10.1038/s41598-017-10316-y
– ident: e_1_3_5_17_2
  doi: 10.1002/anie.201310641
– ident: e_1_3_5_11_2
  doi: 10.1021/acs.orglett.2c02396
– ident: e_1_3_5_77_2
  doi: 10.1002/cbic.201500261
– ident: e_1_3_5_104_2
  doi: 10.1093/nar/gkp377
– ident: e_1_3_5_16_2
  doi: 10.1002/anie.201802488
– ident: e_1_3_5_98_2
  doi: 10.1099/ijs.0.028514-0
– ident: e_1_3_5_32_2
  doi: 10.1111/1751-7915.12116
– ident: e_1_3_5_80_2
  doi: 10.1038/s42003-023-05230-1
– ident: e_1_3_5_18_2
  doi: 10.2174/1568026616666151012112818
– ident: e_1_3_5_105_2
  doi: 10.1128/jb.173.2.697-703.1991
– ident: e_1_3_5_61_2
  doi: 10.1021/jo00041a053
– ident: e_1_3_5_29_2
  doi: 10.7164/antibiotics.25.271
– ident: e_1_3_5_6_2
  doi: 10.1021/acs.jnatprod.0c00900
– ident: e_1_3_5_66_2
  doi: 10.1128/AEM.65.10.4334-4339.1999
– ident: e_1_3_5_51_2
  doi: 10.1128/mBio.02700-21
– ident: e_1_3_5_14_2
  doi: 10.1002/anie.201805673
– ident: e_1_3_5_70_2
  doi: 10.1021/ja303004g
– ident: e_1_3_5_31_2
  doi: 10.1021/acs.orglett.8b01285
– ident: e_1_3_5_93_2
  doi: 10.1093/bioinformatics/btab007
– ident: e_1_3_5_44_2
  doi: 10.3390/microorganisms8040583
– ident: e_1_3_5_41_2
  doi: 10.1021/acs.biochem.2c00575
– ident: e_1_3_5_2_2
  doi: 10.1128/AAC.00931-06
– ident: e_1_3_5_3_2
  doi: 10.1073/pnas.1001513107
– ident: e_1_3_5_67_2
  doi: 10.3389/fmicb.2017.02305
– ident: e_1_3_5_82_2
  doi: 10.1021/acs.analchem.2c04632
– ident: e_1_3_5_57_2
  doi: 10.1094/MPMI-03-11-0073
– ident: e_1_3_5_15_2
  doi: 10.1039/C5CC00843C
– ident: e_1_3_5_19_2
  doi: 10.1039/c6sc03875a
– ident: e_1_3_5_69_2
  doi: 10.3389/fchem.2021.772858
– ident: e_1_3_5_20_2
  doi: 10.1016/j.bioorg.2020.103954
– ident: e_1_3_5_9_2
  doi: 10.1002/anie.201611063
– ident: e_1_3_5_50_2
  doi: 10.1099/mic.0.000572
– ident: e_1_3_5_48_2
  doi: 10.1186/s40168-021-01016-x
– ident: e_1_3_5_83_2
  doi: 10.7554/eLife.65091
– ident: e_1_3_5_52_2
  doi: 10.1371/journal.pone.0039550
– ident: e_1_3_5_101_2
  doi: 10.1128/AEM.02925-14
– ident: e_1_3_5_30_2
  doi: 10.1096/fj.201901237R
– ident: e_1_3_5_55_2
  doi: 10.1099/ijsem.0.005225
– ident: e_1_3_5_73_2
  doi: 10.1073/pnas.2006560117
– ident: e_1_3_5_13_2
  doi: 10.1021/cb500432j
– ident: e_1_3_5_21_2
  doi: 10.1021/acs.jnatprod.1c00606
– ident: e_1_3_5_96_2
  doi: 10.1099/ijs.0.65224-0
– ident: e_1_3_5_56_2
  doi: 10.1128/genomeA.01401-17
– ident: e_1_3_5_24_2
  doi: 10.3390/md17120663
– ident: e_1_3_5_64_2
  doi: 10.1016/j.biortech.2018.10.085
– ident: e_1_3_5_28_2
  doi: 10.1073/pnas.1520289113
– ident: e_1_3_5_5_2
  doi: 10.1128/AEM.01169-17
– ident: e_1_3_5_103_2
  doi: 10.1016/j.syapm.2013.03.010
– ident: e_1_3_5_25_2
  doi: 10.1021/acs.orglett.9b04672
– ident: e_1_3_5_10_2
  doi: 10.3390/md12020999
– ident: e_1_3_5_38_2
  doi: 10.1016/j.tet.2018.10.007
– volume: 53
  start-page: 3011
  year: 2014
  end-page: 3014
  ident: B16
  article-title: Heterologous reconstitution of ikarugamycin biosynthesis in E. coli
  publication-title: Angew Chem Int Ed
  doi: 10.1002/anie.201310641
– volume: 37
  start-page: 2352
  year: 2017
  ident: B7
  article-title: Polycyclic tetramate macrolactams from the marine-derived Actinoalloteichus cyanogriseus WH1-2216-6
  publication-title: Chin J Org Chem
  doi: 10.6023/cjoc201703048
– volume: 4
  year: 2013
  ident: B32
  article-title: Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster
  publication-title: Nat Commun
  doi: 10.1038/ncomms3894
– volume: 12
  year: 2021
  ident: B50
  article-title: Vertical inheritance facilitates interspecies diversification in biosynthetic gene clusters and specialized metabolites
  publication-title: mBio
  doi: 10.1128/mBio.02700-21
– volume: 22
  start-page: 1731
  year: 2020
  end-page: 1735
  ident: B24
  article-title: Engineered biosynthesis of 5/5/6 type polycyclic tetramate macrolactams in an ikarugamycin (5/6/5 type)-producing chassis
  publication-title: Org Lett
  doi: 10.1021/acs.orglett.9b04672
– volume: 34
  start-page: 1065
  year: 1993
  end-page: 1068
  ident: B41
  article-title: Cylindramide: cytotoxic tetramic acid lactam from the marine sponge Halichondria cylindrata Tanita & Hoshino
  publication-title: Tetrahedron Lett
  doi: 10.1016/S0040-4039(00)77493-4
– volume: 37
  start-page: 566
  year: 2020
  end-page: 599
  ident: B71
  article-title: Evolutionary dynamics of natural product biosynthesis in bacteria
  publication-title: Nat Prod Rep
  doi: 10.1039/c9np00048h
– volume: 7
  year: 2017
  ident: B26
  article-title: Structural diversity of anti-pancreatic cancer capsimycins identified in mangrove-derived Streptomyces xiamenensis 318 and post-modification via a novel cytochrome P450 monooxygenase
  publication-title: Sci Rep
  doi: 10.1038/srep40689
– volume: 113
  start-page: E3725
  year: 2016
  end-page: 34
  ident: B27
  article-title: Connectivity mapping (ssCMap) to predict A20-inducing drugs and their antiinflammatory action in cystic fibrosis
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1520289113
– volume: 9
  start-page: 818
  year: 2013
  end-page: 825
  ident: B75
  article-title: Distinct mechanisms for spiro-carbon formation reveal biosynthetic pathway crosstalk
  publication-title: Nat Chem Biol
  doi: 10.1038/nchembio.1366
– volume: 2
  start-page: 212
  year: 2010
  end-page: 224
  ident: B73
  article-title: The sequence of a 1.8-MB bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways
  publication-title: Genome Biol Evol
  doi: 10.1093/gbe/evq013
– volume: 12
  start-page: 4652
  year: 2010
  end-page: 4654
  ident: B33
  article-title: Targeted discovery of polycyclic tetramate macrolactams from an environmental Streptomyces strain
  publication-title: Org Lett
  doi: 10.1021/ol1020064
– volume: 205
  year: 2023
  ident: B58
  article-title: A novel pathway for biosynthesis of the herbicidal phosphonate natural product phosphonothrixin is widespread in actinobacteria
  publication-title: J Bacteriol
  doi: 10.1128/jb.00485-22
– volume: 114
  start-page: 346
  year: 2017
  end-page: 352
  ident: B59
  article-title: A whole genome analysis reveals the presence of a plant PR1 sequence in the potato pathogen Streptomyces scabies and other Streptomyces species
  publication-title: Mol Phylogenet Evol
  doi: 10.1016/j.ympev.2016.08.006
– volume: 83
  start-page: 2803
  year: 2020
  end-page: 2808
  ident: B5
  article-title: Expression of the clifednamide biosynthetic pathway in Streptomyces generates 27,28-seco-derivatives
  publication-title: J Nat Prod
  doi: 10.1021/acs.jnatprod.0c00900
– volume: 58
  start-page: 5245
  year: 2019
  end-page: 5248
  ident: B39
  article-title: Ox4 is an NADPH-dependent dehydrogenase catalyzing an extended Michael addition reaction to form the six-membered ring in the antifungal HSAF
  publication-title: Biochemistry
  doi: 10.1021/acs.biochem.9b00280
– volume: 16
  year: 2021
  ident: B94
  article-title: Unexpected distribution of the 4-formylaminooxyvinylglycine (FVG) biosynthetic pathway in Pseudomonas and beyond
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0247348
– volume: 51
  start-page: 64
  year: 2007
  end-page: 72
  ident: B1
  article-title: Structure and biosynthesis of heat-stable antifungal factor (HSAF), a broad-spectrum antimycotic with a novel mode of action
  publication-title: Antimicrob Agents Chemother
  doi: 10.1128/AAC.00931-06
– volume: 94
  start-page: 11959
  year: 2022
  end-page: 11966
  ident: B77
  article-title: Integrated metabolomic–genomic workflows accelerate microbial natural product discovery
  publication-title: Anal Chem
  doi: 10.1021/acs.analchem.2c02245
– volume: 84
  year: 2018
  ident: B3
  article-title: Discovery and biosynthesis of the antibiotic bicyclomycin in distantly related bacterial classes
  publication-title: Appl Environ Microbiol
  doi: 10.1128/AEM.02828-17
– volume: 78
  start-page: 1841
  year: 2015
  end-page: 1847
  ident: B36
  article-title: Bioactive polycyclic tetramate macrolactams from Lysobacter enzymogenes and their absolute configurations by theoretical ECD calculations
  publication-title: J Nat Prod
  doi: 10.1021/acs.jnatprod.5b00099
– volume: 7
  year: 2012
  ident: B51
  article-title: On the structure and function of the phytoene desaturase CRTI from Pantoea ananatis, a membrane-peripheral and FAD-dependent oxidase/isomerase
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0039550
– volume: 117
  start-page: 17195
  year: 2020
  end-page: 17203
  ident: B72
  article-title: Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.2006560117
– volume: 8
  year: 2017
  ident: B66
  article-title: Diverse cone-snail species harbor closely related Streptomyces species with conserved chemical and genetic profiles, including polycyclic tetramic acid macrolactams
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2017.02305
– volume: 16
  start-page: 1925
  year: 2015
  end-page: 1932
  ident: B76
  article-title: Crosstalk of nataxazole pathway with chorismate-derived ionophore biosynthesis pathways in Streptomyces sp. Tü 6176
  publication-title: Chembiochem
  doi: 10.1002/cbic.201500261
– volume: 47
  start-page: W81
  year: 2019
  end-page: W87
  ident: B89
  article-title: antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkz310
– start-page: 181
  year: 2009
  end-page: 217
  ident: B91
  article-title: Chapter 8. Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data
  publication-title: In methods in enzymology ;p In ;Elsevier
– volume: 7
  year: 2017
  ident: B67
  article-title: Identification of butenolide regulatory system controlling secondary metabolism in Streptomyces albus J1074
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-10316-y
– volume: 36
  start-page: 401
  year: 2013
  end-page: 407
  ident: B102
  article-title: Classification of Streptomyces phylogroup pratensis (Doroghazi and Buckley, 2010) based on genetic and phenotypic evidence, and proposal of Streptomyces pratensis sp. nov
  publication-title: Syst Appl Microbiol
  doi: 10.1016/j.syapm.2013.03.010
– volume: 8
  start-page: 1607
  year: 2017
  end-page: 1612
  ident: B18
  article-title: Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams
  publication-title: Chem Sci
  doi: 10.1039/c6sc03875a
– volume: 49
  start-page: 1101
  year: 1996
  end-page: 1104
  ident: B62
  article-title: Maltophilin: a new antifungal compound produced by Stenotrophomonas maltophilia R3089
  publication-title: J Antibiot (Tokyo)
  doi: 10.7164/antibiotics.49.1101
– volume: 74
  start-page: 6839
  year: 2018
  end-page: 6845
  ident: B37
  article-title: New polycyclic tetramate macrolactams from marine-derived Streptomyces sp. SCSIO 40060
  publication-title: Tetrahedron
  doi: 10.1016/j.tet.2018.10.007
– volume: 6
  year: 2023
  ident: B79
  article-title: Microbiomes and metabolomes of dominant coral reef primary producers illustrate a potential role for immunolipids in marine symbioses
  publication-title: Commun Biol
  doi: 10.1038/s42003-023-05230-1
– volume: 10
  year: 2021
  ident: B82
  article-title: Multiple lineages of Streptomyces produce antimicrobials within passalid beetle galleries across Eastern North America
  publication-title: Elife
  doi: 10.7554/eLife.65091
– volume: 7
  start-page: 242
  year: 2014
  end-page: 256
  ident: B31
  article-title: Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074
  publication-title: Microb Biotechnol
  doi: 10.1111/1751-7915.12116
– volume: 120
  year: 2023
  ident: B80
  article-title: Plant and microbial sciences as key drivers in the development of metabolomics research
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.2217383120
– volume: 85
  start-page: 462
  year: 2022
  end-page: 478
  ident: B87
  article-title: Metabolomics approaches to dereplicate natural products from coral-derived bioactive bacteria
  publication-title: J Nat Prod
  doi: 10.1021/acs.jnatprod.1c01110
– volume: 53
  start-page: 4840
  year: 2014
  end-page: 4844
  ident: B34
  article-title: Mechanistic insights into polycycle formation by reductive cyclization in ikarugamycin biosynthesis
  publication-title: Angew Chem Int Ed
  doi: 10.1002/anie.201402078
– volume: 273
  start-page: 196
  year: 2019
  end-page: 202
  ident: B63
  article-title: Improving the production of a novel antifungal alteramide B in Lysobacter enzymogenes OH11 by strengthening metabolic flux and precursor supply
  publication-title: Bioresour Technol
  doi: 10.1016/j.biortech.2018.10.085
– volume: 20
  start-page: 3504
  year: 2018
  end-page: 3508
  ident: B30
  article-title: Targeted discovery and combinatorial biosynthesis of polycyclic tetramate macrolactam combamides A–E
  publication-title: Org Lett
  doi: 10.1021/acs.orglett.8b01285
– volume: 61
  start-page: 2525
  year: 2011
  end-page: 2531
  ident: B97
  article-title: Multilocus sequence analysis of phytopathogenic species of the genus Streptomyces
  publication-title: Int J Syst Evol Microbiol
  doi: 10.1099/ijs.0.028514-0
– volume: 25
  start-page: 271
  year: 1972
  end-page: 280
  ident: B28
  article-title: A new antibiotic, ikarugamycin
  publication-title: J Antibiot (Tokyo)
  doi: 10.7164/antibiotics.25.271
– volume: 10
  start-page: 873
  year: 2017
  end-page: 885
  ident: B74
  article-title: Caboxamycin biosynthesis pathway and identification of novel benzoxazoles produced by cross‐talk in Streptomyces sp. NTK 937
  publication-title: Microb Biotechnol
  doi: 10.1111/1751-7915.12716
– volume: 51
  start-page: 5334
  year: 2015
  end-page: 5336
  ident: B14
  article-title: Promiscuous hydroxylases for the functionalization of polycyclic tetramate macrolactams – conversion of ikarugamycin to butremycin
  publication-title: Chem. Commun
  doi: 10.1039/C5CC00843C
– volume: 101
  start-page: 103954
  year: 2020
  ident: B19
  article-title: Targeted isolation of new polycyclic tetramate macrolactams from the deepsea-derived Streptomyces somaliensis SCSIO ZH66
  publication-title: Bioorg Chem
  doi: 10.1016/j.bioorg.2020.103954
– volume: 9
  year: 2018
  ident: B84
  article-title: New alpiniamides from Streptomyces sp. IB2014/011-12 assembled by an unusual hybrid non-ribosomal peptide synthetase trans-AT polyketide synthase enzyme
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2018.01959
– volume: 9
  year: 2021
  ident: B57
  article-title: Identification of novel rotihibin analogues in Streptomyces scabies, including discovery of its biosynthetic gene cluster
  publication-title: Microbiol Spectr
  doi: 10.1128/spectrum.00571-21
– volume: 25
  start-page: 393
  year: 2012
  end-page: 401
  ident: B56
  article-title: Evidence that thaxtomin C is a pathogenicity determinant of Streptomyces ipomoeae, the causative agent of Streptomyces soil rot disease of sweet potato
  publication-title: Mol Plant Microbe Interact
  doi: 10.1094/MPMI-03-11-0073
– volume: 34
  start-page: 39
  year: 2021
  end-page: 48
  ident: B101
  article-title: A novel species-level group of Streptomyces exhibits variation in phytopathogenicity despite conservation of virulence loci
  publication-title: Mol Plant Microbe Interact
  doi: 10.1094/MPMI-06-20-0164-R
– volume: 37
  start-page: 2473
  year: 2021
  end-page: 2475
  ident: B92
  article-title: clinker & clustermap.js: automatic generation of gene cluster comparison figures
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btab007
– volume: 85
  start-page: 47
  year: 2022
  end-page: 55
  ident: B20
  article-title: Multifunctional P450 monooxygenase CftA diversifies the clifednamide pool through tandem C–H bond activations
  publication-title: J Nat Prod
  doi: 10.1021/acs.jnatprod.1c00606
– volume: 134
  start-page: 8996
  year: 2012
  end-page: 9005
  ident: B69
  article-title: Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis
  publication-title: J Am Chem Soc
  doi: 10.1021/ja303004g
– volume: 10
  start-page: 907
  year: 2019
  end-page: 912
  ident: B35
  article-title: Construction of a hybrid gene cluster to reveal coupled ring formation–hydroxylation in the biosynthesis of HSAF and analogues from Lysobacter enzymogenes
  publication-title: Med Chem Commun
  doi: 10.1039/C9MD00154A
– volume: 46
  start-page: 257
  year: 2019
  end-page: 271
  ident: B70
  article-title: Emerging evolutionary paradigms in antibiotic discovery
  publication-title: J Ind Microbiol Biotechnol
  doi: 10.1007/s10295-018-2085-6
– volume: 65
  start-page: 4334
  year: 1999
  end-page: 4339
  ident: B65
  article-title: Possible role of xanthobaccins produced by Stenotrophomonas sp. strain SB-K88 in suppression of sugar beet damping-off disease
  publication-title: Appl Environ Microbiol
  doi: 10.1128/AEM.65.10.4334-4339.1999
– volume: 12
  start-page: 999
  year: 2014
  end-page: 1012
  ident: B9
  article-title: Butremycin, the 3-hydroxyl derivative of ikarugamycin and a protonated aromatic tautomer of 5′-methylthioinosine from a Ghanaian Micromonospora sp. K310. 2
  publication-title: Mar Drugs
  doi: 10.3390/md12020999
– volume: 89
  year: 2023
  ident: B46
  article-title: Horizontal gene transfer and CRISPR targeting drive phage-bacterial host interactions and coevolution in “pink berry” marine microbial aggregates
  publication-title: bioRxiv
  doi: 10.1101/2023.02.06.527410
– volume: 9
  year: 2021
  ident: B47
  article-title: Revealing taxon-specific heavy metal-resistance mechanisms in denitrifying phosphorus removal sludge using genome-centric metaproteomics
  publication-title: Microbiome
  doi: 10.1186/s40168-021-01016-x
– volume: 9
  year: 2020
  ident: B88
  article-title: Draft genome sequences of two polycyclic tetramate macrolactam producers, Streptomyces sp. strains JV180 and SP18CM02
  publication-title: Microbiol Resour Announc
  doi: 10.1128/MRA.01066-20
– volume: 57
  start-page: 14519
  year: 2018
  end-page: 14523
  ident: B13
  article-title: Genome-based identification of a plant-associated marine bacterium as a rich natural product source
  publication-title: Angew Chem Int Ed
  doi: 10.1002/anie.201805673
– volume: 173
  start-page: 697
  year: 1991
  end-page: 703
  ident: B104
  article-title: 16S ribosomal DNA amplification for phylogenetic study
  publication-title: J Bacteriol
  doi: 10.1128/jb.173.2.697-703.1991
– volume: 71
  start-page: 653
  year: 2018
  end-page: 657
  ident: B11
  article-title: Umezawamides, new bioactive polycyclic tetramate macrolactams isolated from a combined-culture of Umezawaea sp. and mycolic acid-containing bacterium
  publication-title: J Antibiot
  doi: 10.1038/s41429-018-0040-4
– volume: 2
  start-page: 315
  year: 1996
  end-page: 318
  ident: B61
  article-title: Aburatubolactam A, a novel inhibitor of superoxide anion generation from a marine microorganism
  publication-title: Heterocycl Commun
  doi: 10.1515/HC.1996.2.4.315
– volume: 24
  start-page: 6515
  year: 2022
  end-page: 6519
  ident: B10
  article-title: Discovery of oxidized polycyclic tetramate macrolactams bearing one or two rings through combinatorial pathway reassembly
  publication-title: Org Lett
  doi: 10.1021/acs.orglett.2c02396
– volume: 72
  start-page: 005225
  year: 2022
  ident: B54
  article-title: Streptomyces caniscabiei sp. nov., which causes potato common scab and is distributed across the world
  publication-title: Int J Syst Evol Microbiol
  doi: 10.1099/ijsem.0.005225
– volume: 6
  year: 2018
  ident: B55
  article-title: Draft genome sequence of Streptomyces sp. strain JV178, a producer of clifednamide-type polycyclic tetramate macrolactams
  publication-title: Genome Announc
  doi: 10.1128/genomeA.01401-17
– volume: 60
  start-page: 696
  year: 2010
  end-page: 703
  ident: B96
  article-title: Taxonomic evaluation of the Streptomyces griseus clade using multilocus sequence analysis and DNA–DNA hybridization, with proposal to combine 29 species and three subspecies as 11 genomic species
  publication-title: Int J Syst Evol Microbiol
  doi: 10.1099/ijs.0.012419-0
– volume: 62
  start-page: 1256
  year: 1999
  end-page: 1259
  ident: B42
  article-title: Geodin A magnesium salt: a novel nematocide from a southern Australian marine sponge, Geodia
  publication-title: J Nat Prod
  doi: 10.1021/np990144v
– volume: 9
  year: 2021
  ident: B68
  article-title: Polycyclic tetramate macrolactams – a group of natural bioactive metallophores
  publication-title: Front Chem
  doi: 10.3389/fchem.2021.772858
– volume: 61
  start-page: 2879
  year: 2022
  end-page: 2883
  ident: B40
  article-title: Identification and characterization of the 28-N-methyltransferase involved in HSAF analogue biosynthesis
  publication-title: Biochemistry
  doi: 10.1021/acs.biochem.2c00575
– volume: 5
  start-page: 643225
  year: 2021
  ident: B85
  article-title: Evaluation of apple root-associated endophytic Streptomyces pulveraceus strain ES16 by an OSMAC-assisted metabolomics approach
  publication-title: Front Sustain Food Syst
  doi: 10.3389/fsufs.2021.643225
– volume: 16
  start-page: 1921
  year: 2022
  end-page: 1931
  ident: B45
  article-title: Metagenomic methylation patterns resolve bacterial genomes of unusual size and structural complexity
  publication-title: ISME J
  doi: 10.1038/s41396-022-01242-7
– volume: 35
  start-page: 251
  year: 2000
  end-page: 259
  ident: B52
  article-title: Adaptation to the environment: Streptococcus pneumoniae, a paradigm for recombination‐mediated genetic plasticity?
  publication-title: Mol Microbiol
  doi: 10.1046/j.1365-2958.2000.01718.x
– volume: 110
  start-page: 563
  year: 2017
  end-page: 583
  ident: B93
  article-title: Phylogenetic relationships in the family Streptomycetaceae using multi-locus sequence analysis
  publication-title: Antonie van Leeuwenhoek
  doi: 10.1007/s10482-016-0824-0
– volume: 13
  start-page: 4760
  year: 2023
  end-page: 4767
  ident: B48
  article-title: Discovery and biosynthesis of pseudoamides reveal enzymatic cyclization of the polyene precursor to 5–5 bicyclic tetramate macrolactams
  publication-title: ACS Catal
  doi: 10.1021/acscatal.2c05784
– volume: 95
  start-page: 8770
  year: 2023
  end-page: 8779
  ident: B81
  article-title: Metabolomics peak analysis computational tool (MPACT): an advanced Informatics tool for metabolomics and data visualization of molecules from complex biological samples
  publication-title: Anal Chem
  doi: 10.1021/acs.analchem.2c04632
– volume: 64
  start-page: 894
  year: 2014
  end-page: 900
  ident: B99
  article-title: Taxonomic evaluation of Streptomyces albus and related species using multilocus sequence analysis and proposals to emend the description of Streptomyces albus and describe Streptomyces pathocidini sp. nov
  publication-title: Int J Syst Evol Microbiol
  doi: 10.1099/ijs.0.058107-0
– volume: 164
  start-page: 28
  year: 2018
  end-page: 39
  ident: B49
  article-title: A phylogenetic and evolutionary analysis of antimycin biosynthesis
  publication-title: Microbiology (Reading)
  doi: 10.1099/mic.0.000572
– year: 2012
  ident: B98
  publication-title: Bergey’s manual of systematic bacteriology ;Springer New York, New York, NY
– volume: 19
  year: 2021
  ident: B21
  article-title: Genome mining and metabolic profiling uncover polycyclic tetramate macrolactams from Streptomyces koyangensis SCSIO 5802
  publication-title: Mar Drugs
  doi: 10.3390/md19080440
– volume: 57
  start-page: 4317
  year: 1992
  end-page: 4320
  ident: B60
  article-title: Alteramide A, a new tetracyclic alkaloid from a bacterium Alteromonas sp. associated with the marine sponge Halichondria okadai
  publication-title: J Org Chem
  doi: 10.1021/jo00041a053
– volume: 9
  start-page: 2300
  year: 2014
  end-page: 2308
  ident: B12
  article-title: Microbiota of healthy corals are active against fungi in a light-dependent manner
  publication-title: ACS Chem Biol
  doi: 10.1021/cb500432j
– volume: 118
  year: 2021
  ident: B38
  article-title: A comparative metabologenomic approach reveals mechanistic insights into Streptomyces antibiotic crypticity
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.2103515118
– volume: 58
  start-page: 149
  year: 2008
  end-page: 159
  ident: B95
  article-title: A multilocus phylogeny of the Streptomyces griseus 16S rRNA gene clade: use of multilocus sequence analysis for streptomycete systematics
  publication-title: Int J Syst Evol Microbiol
  doi: 10.1099/ijs.0.65224-0
– volume: 37
  start-page: W95
  year: 2009
  end-page: W100
  ident: B103
  article-title: Primers4clades: a web server that uses phylogenetic trees to design lineage-specific PCR primers for metagenomic and diversity studies
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkp377
– volume: 83
  year: 2017
  ident: B4
  article-title: Coronafacoyl phytotoxin biosynthesis and evolution in the common scab pathogen Streptomyces scabiei
  publication-title: Appl Environ Microbiol
  doi: 10.1128/AEM.01169-17
– volume: 56
  start-page: 4351
  year: 2017
  end-page: 4355
  ident: B8
  article-title: Biocatalytic total synthesis of ikarugamycin
  publication-title: Angew Chem Int Ed
  doi: 10.1002/anie.201611063
– volume: 20
  start-page: 21
  year: 2021
  ident: B83
  article-title: The diversity, metabolomics profiling, and the pharmacological potential of actinomycetes isolated from the Estremadura Spur pockmarks (Portugal)
  publication-title: Marine Drugs
  doi: 10.3390/md20010021
– volume: 16
  start-page: 1727
  year: 2016
  end-page: 1739
  ident: B17
  article-title: Recent advances in discovery, biosynthesis and genome mining of medicinally relevant polycyclic tetramate macrolactams
  publication-title: Curr Top Med Chem
  doi: 10.2174/1568026616666151012112818
– volume: 17
  year: 2019
  ident: B23
  article-title: Genome mining of marine-derived Streptomyces sp. SCSIO 40010 leads to cytotoxic new polycyclic tetramate macrolactams
  publication-title: Mar Drugs
  doi: 10.3390/md17120663
– volume: 57
  start-page: 6221
  year: 2018
  end-page: 6225
  ident: B15
  article-title: Biosynthesis of the polycyclic system in the antifungal HSAF and analogues from Lysobacter enzymogenes
  publication-title: Angew Chem Int Ed Engl
  doi: 10.1002/anie.201802488
– volume: 81
  start-page: 966
  year: 2015
  end-page: 975
  ident: B100
  article-title: Population genetic analysis of Streptomyces albidoflavus reveals habitat barriers to homologous recombination in the diversification of streptomycetes
  publication-title: Appl Environ Microbiol
  doi: 10.1128/AEM.02925-14
– volume: 10
  start-page: 2434
  year: 2021
  end-page: 2439
  ident: B22
  article-title: Combinatorial biosynthesis of oxidized combamides using cytochrome P450 enzymes from different polycyclic tetramate macrolactam pathways
  publication-title: ACS Synth Biol
  doi: 10.1021/acssynbio.1c00178
– volume: 34
  start-page: 3943
  year: 2020
  end-page: 3955
  ident: B29
  article-title: Ikarugamycin inhibits pancreatic cancer cell glycolysis by targeting hexokinase 2
  publication-title: FASEB J
  doi: 10.1096/fj.201901237R
– volume: 113
  start-page: 1573
  year: 2020
  end-page: 1585
  ident: B53
  article-title: Control of the rubber anthracnose fungus Colletotrichum gloeosporioides using culture filtrate extract from Streptomyces deccanensis QY-3
  publication-title: Antonie Van Leeuwenhoek
  doi: 10.1007/s10482-020-01465-8
– volume: 12
  start-page: 1223
  year: 2017
  end-page: 1226
  ident: B25
  article-title: Chlokamycin, a new chloride from the marine-derived Streptomyces sp. MA2-12
  publication-title: Nat Prod Commun
  doi: 10.1177/1934578X1701200818
– volume: 50
  start-page: 1014
  year: 1997
  end-page: 1019
  ident: B64
  article-title: Dihydromaltophilin; a novel fungicidal tetramic acid containing metabolite from Streptomyces sp
  publication-title: J Antibiot (Tokyo)
  doi: 10.7164/antibiotics.50.1014
– volume: 107
  start-page: 11692
  year: 2010
  end-page: 11697
  ident: B2
  article-title: Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1001513107
– volume: 8
  start-page: 583
  year: 2020
  ident: B43
  article-title: Mechanisms underlying the rhizosphere-to-rhizoplane enrichment of Cellvibrio unveiled by genome-centric metagenomics and metatranscriptomics
  publication-title: Microorganisms
  doi: 10.3390/microorganisms8040583
– volume: 28
  start-page: 426
  year: 2012
  end-page: 427
  ident: B90
  article-title: NRPSsp: non-ribosomal peptide synthase substrate predictor
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btr659
– volume: 4
  start-page: 195
  year: 2020
  end-page: 210
  ident: B78
  article-title: Metabolomics, an essential tool in exploring and harnessing microbial chemical ecology
  publication-title: Phytobiomes
  doi: 10.1094/PBIOMES-04-20-0032-RVW
– volume: 7
  start-page: 357
  year: 2018
  end-page: 362
  ident: B6
  article-title: Native and engineered clifednamide biosynthesis in multiple Streptomyces spp
  publication-title: ACS Synth Biol
  doi: 10.1021/acssynbio.7b00349
– volume: 11
  year: 2021
  ident: B86
  article-title: Specialized metabolites from ribosome engineered strains of Streptomyces clavuligerus
  publication-title: Metabolites
  doi: 10.3390/metabo11040239
– volume: 16
  start-page: 3398
  year: 2014
  end-page: 3415
  ident: B44
  article-title: Microscale sulfur cycling in the phototrophic pink berry consortia of the Sippewissett Salt Marsh
  publication-title: Environ Microbiol
  doi: 10.1111/1462-2920.12388
SSID ssj0004068
Score 2.4784832
Snippet Polycyclic tetramate macrolactam (PTM) pathways are frequently found within the genomes of biotechnologically important bacteria, including Streptomyces and...
Polycyclic tetramate macrolactams (PTMs) are bioactive natural products commonly associated with certain actinobacterial and proteobacterial lineages. These...
SourceID pubmedcentral
proquest
asm2
pubmed
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage e0060024
SubjectTerms Bioinformatics
Biosynthesis
Biosynthetic Pathways - genetics
Biotechnology
Complexity
Computational Biology
Gene clusters
Genetics and Molecular Biology
Lactams - metabolism
Lysobacter - classification
Lysobacter - genetics
Lysobacter - metabolism
Metabolomics
Multigene Family
Natural products
Phylogeny
Streptomyces - classification
Streptomyces - genetics
Streptomyces - metabolism
Title Critical analysis of polycyclic tetramate macrolactam biosynthetic gene cluster phylogeny and functional diversity
URI https://www.ncbi.nlm.nih.gov/pubmed/38771054
https://journals.asm.org/doi/10.1128/aem.00600-24
https://www.proquest.com/docview/3070029809
https://www.proquest.com/docview/3057693454
https://pubmed.ncbi.nlm.nih.gov/PMC11218653
Volume 90
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELbKIgQcEJRXYUEGwanKkpcT-4h4aAVaBFJX2lvkOI6o1KZVmx7Cf-A_MxMnjrt0pYVLVCWuE3W-zHx2Z74h5E0qyoJFZeApiHUeeMnIkzoSXiCLQPIykkHbY-nsW3J6Hn-5YBej0W8na2lX5yfq18G6kv-xKpwDu2KV7D9Y1k4KJ-Az2BeOYGE4XsvGtk-BdKRF1qtFoxqF4tW1rjcSKCkmqYLDXUhVy-U0n6-2TQXED7VaYW49VYsd6iXgNge4Ql0ZTSYMed1OYdFnb7hctiewONapl8NylPkg7zS4uM26Kzoc9Aym30-GrfLGJFhWNlDMcB_DpAGeycae_ti1YTH9pt1tizDG9CrX07bSoMgnTCAy3hfFTYF_Jq57Nt1EOxgmh71-iJUMUi8xS8_3PVOVvS-ufSno2VTEdhEU8gy-nbXfzsL4BrkZwqoDG2J8_eGIz_sJ70VN8cn7OoqQv3PvDcFdbpfhPtH5a_VyOQnXYTWz--Retxyh7w22HpCRrsbklmlQ2ozJ7b5ufTsmdx3pyodk02OP9tijq5IO2KMWe9TBHnWxRxF7tMMetdiDCQs6YI9a7D0i558_zT6cel3_Dk_GcVp7LJAikUr5QakEK6SI8lRwJcMo50CDEp7nHBZ4rOCq9GWZCKELDaQt9JVkKhLRY3JUrSr9lFAtWAmhIi4EEPgwV0L7Ok4LptJclYWMJ-Q1_uZZ93Jus0NmnZBpb5FMdQr42IhlccXot3b02ii_XDHuuDfucHuMpNjcwBcT8speBs-Nf8fJSq92OIZhI9KYwRRPDBbsjSKeAvXHK3wPJXYAqsLvX6nmP1t1eHjAgCcsenbN539O7gzv5zE5qjc7_QKIdp2_bOH_B95I2vA
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Critical+analysis+of+polycyclic+tetramate+macrolactam+biosynthetic+gene+cluster+phylogeny+and+functional+diversity&rft.jtitle=Applied+and+environmental+microbiology&rft.au=Harper%2C+Christopher+P.&rft.au=Day%2C+Anna&rft.au=Tsingos%2C+Maya&rft.au=Ding%2C+Edward&rft.date=2024-06-18&rft.issn=0099-2240&rft.eissn=1098-5336&rft.volume=90&rft.issue=6&rft_id=info:doi/10.1128%2Faem.00600-24&rft.externalDBID=n%2Fa&rft.externalDocID=10_1128_aem_00600_24
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0099-2240&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0099-2240&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0099-2240&client=summon