Susceptibilities of Human ACE2 Genetic Variants in Coronavirus Infection

• Published in: Journal of virology Vol. 96; no. 1; p. e0149221
• Main Authors: Ren, Wenlin, Zhu, Yunkai, Lan, Jun, Chen, Hedi, Wang, Yuyan, Shi, Hongyang, Feng, Fei, Chen, Da-Yuan, Close, Brianna, Zhao, Xiaomin, Wu, Jianping, Tian, Boxue, Yuan, Zhenghong, Zhou, Dongming, Saeed, Mohsan, Wang, Xinquan, Zhang, Rong, Ding, Qiang
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 12.01.2022
• Subjects: Angiotensin-Converting Enzyme 2 - genetics; Angiotensin-Converting Enzyme 2 - metabolism; COVID-19 - genetics; Genetic Predisposition to Disease - genetics; Genetic Variation; Humans; Polymorphism, Single Nucleotide; Protein Binding; SARS-CoV-2 - metabolism; SARS-CoV-2 - pathogenicity; Spike Glycoprotein, Coronavirus - metabolism; Virology; Virus Internalization; Virus-Cell Interactions; COVID-19; ACE2; SARS-CoV-2; SNP; HCoV-NL63; SARS-CoV

There is considerable variation in disease severity among patients infected with SARS-CoV-2, the virus that causes COVID-19. Human genetic variation can affect disease outcome, and the coronaviruses SARS-CoV, SARS-CoV-2, and HCoV-NL63 utilize human ACE2 as the receptor to enter cells. The coronaviru...