Structure–Activity Relationship of Penem Antibiotic Side Chains Used against Mycobacteria Reveals Highly Active Compounds
The rise of antibiotic-resistant Mycobacterium tuberculosis and non-tuberculous mycobacterial infections has placed ever-increasing importance on discovering new antibiotics to treat these diseases. Recently, a new penem, T405, was discovered to have strong antimicrobial activity against M. tubercul...
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Published in | ACS infectious diseases Vol. 8; no. 8; pp. 1627 - 1636 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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American Chemical Society
12.08.2022
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Abstract | The rise of antibiotic-resistant Mycobacterium tuberculosis and non-tuberculous mycobacterial infections has placed ever-increasing importance on discovering new antibiotics to treat these diseases. Recently, a new penem, T405, was discovered to have strong antimicrobial activity against M. tuberculosis and Mycobacteroides abscessus. Here, a penem library of C2 side-chain variants was synthesized, and their antimicrobial activities were evaluated against M. tuberculosis H37Rv and M. abscessus ATCC 19977. Several new penems with antimicrobial activity stronger than the standard-of-care carbapenem antibiotics were identified with some candidates improving on the activity of the lead compound, T405. Moreover, many candidates showed little or no increase in the minimum inhibitory concentration in the presence of serum compared to the highly protein-bound T405. The penems with the strongest activity identified in this study were then biochemically characterized by reaction with the representative l,d-transpeptidase LdtMt2 and the representative penicillin-binding protein d,d-carboxypeptidase DacB2. |
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AbstractList | The rise of antibiotic-resistant
Mycobacterium tuberculosis
and non- tuberculous mycobacterial infections has placed ever-increasing importance on discovering new antibiotics to treat these diseases. Recently, a new penem,
T405
, was discovered to have strong antimicrobial activity against
M. tuberculosis
and
Mycobacteroides abscessus
. Here, a penem library of C2 side-chain variants was synthesized, and their antimicrobial activities were evaluated against
M. tuberculosis
H
37
Rv and
M. abscessus
ATCC 19977. Several new penems with antimicrobial activity stronger than the standard-of-care carbapenem antibiotics were identified with some candidates improving on the activity of the lead compound,
T405
. Moreover, many candidates showed little or no increase in the minimum inhibitory concentration in the presence of serum compared to the highly protein-bound
T405
. The penems with the strongest activity identified in this study were then biochemically characterized by reaction with the representative
L
,
D
-transpeptidase Ldt
Mt2
and the representative penicillin-binding protein
D
,
D
-carboxypeptidase DacB2. The rise of antibiotic-resistant Mycobacterium tuberculosis and non-tuberculous mycobacterial infections has placed ever-increasing importance on discovering new antibiotics to treat these diseases. Recently, a new penem, T405, was discovered to have strong antimicrobial activity against M. tuberculosis and Mycobacteroides abscessus. Here, a penem library of C2 side-chain variants was synthesized, and their antimicrobial activities were evaluated against M. tuberculosis H37Rv and M. abscessus ATCC 19977. Several new penems with antimicrobial activity stronger than the standard-of-care carbapenem antibiotics were identified with some candidates improving on the activity of the lead compound, T405. Moreover, many candidates showed little or no increase in the minimum inhibitory concentration in the presence of serum compared to the highly protein-bound T405. The penems with the strongest activity identified in this study were then biochemically characterized by reaction with the representative l,d-transpeptidase LdtMt2 and the representative penicillin-binding protein d,d-carboxypeptidase DacB2. The rise of antibiotic-resistant and non-tuberculous mycobacterial infections has placed ever-increasing importance on discovering new antibiotics to treat these diseases. Recently, a new penem, , was discovered to have strong antimicrobial activity against and . Here, a penem library of C2 side-chain variants was synthesized, and their antimicrobial activities were evaluated against H Rv and ATCC 19977. Several new penems with antimicrobial activity stronger than the standard-of-care carbapenem antibiotics were identified with some candidates improving on the activity of the lead compound, . Moreover, many candidates showed little or no increase in the minimum inhibitory concentration in the presence of serum compared to the highly protein-bound . The penems with the strongest activity identified in this study were then biochemically characterized by reaction with the representative l,d-transpeptidase Ldt and the representative penicillin-binding protein d,d-carboxypeptidase DacB2. |
Author | Batchelder, Hunter R. Kaushik, Amit Townsend, Craig A. Naik, Akul Zandi, Trevor A. Nuermberger, Eric L. Lamichhane, Gyanu Maggioncalda, Emily C. Story-Roller, Elizabeth |
AuthorAffiliation | Department of Chemistry T. C. Jenkins Department of Biophysics Johns Hopkins University Johns Hopkins University School of Medicine Center for Tuberculosis Research, Division of Infectious Diseases |
AuthorAffiliation_xml | – name: T. C. Jenkins Department of Biophysics – name: Department of Chemistry – name: Center for Tuberculosis Research, Division of Infectious Diseases – name: Johns Hopkins University School of Medicine – name: Johns Hopkins University |
Author_xml | – sequence: 1 givenname: Hunter R. surname: Batchelder fullname: Batchelder, Hunter R. organization: Department of Chemistry – sequence: 2 givenname: Trevor A. surname: Zandi fullname: Zandi, Trevor A. organization: Johns Hopkins University – sequence: 3 givenname: Amit surname: Kaushik fullname: Kaushik, Amit organization: Johns Hopkins University School of Medicine – sequence: 4 givenname: Akul surname: Naik fullname: Naik, Akul organization: Department of Chemistry – sequence: 5 givenname: Elizabeth surname: Story-Roller fullname: Story-Roller, Elizabeth organization: Johns Hopkins University School of Medicine – sequence: 6 givenname: Emily C. surname: Maggioncalda fullname: Maggioncalda, Emily C. organization: Johns Hopkins University School of Medicine – sequence: 7 givenname: Gyanu surname: Lamichhane fullname: Lamichhane, Gyanu organization: Johns Hopkins University School of Medicine – sequence: 8 givenname: Eric L. surname: Nuermberger fullname: Nuermberger, Eric L. organization: Johns Hopkins University School of Medicine – sequence: 9 givenname: Craig A. orcidid: 0000-0003-2795-7585 surname: Townsend fullname: Townsend, Craig A. email: ctownsend@jhu.edu organization: Department of Chemistry |
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Keywords | antibiotic penem structure−activity relationship M. abscessus β-lactam M. tuberculosis |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 The study was conceived and directed by C.A.T, G.L., and E.L.N. Synthesis of all new penems was carried out by H.R.B. and A.N. A.K., E.S-R., and E.C.M. undertook microbiological studies, and with E.L.N. and G.L. analyzed the data. T.A.Z. expressed and purified LdtMt2 and DacB2. T.A.Z. performed intact protein UPLC–MS experiments and interpreted the data. H.R.B,,T.A.Z., C.A.T., G.L, and E.L.N. all contributed to the interpretation of data and writing the paper. Author Contributions |
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Snippet | The rise of antibiotic-resistant Mycobacterium tuberculosis and non-tuberculous mycobacterial infections has placed ever-increasing importance on discovering... The rise of antibiotic-resistant and non-tuberculous mycobacterial infections has placed ever-increasing importance on discovering new antibiotics to treat... The rise of antibiotic-resistant Mycobacterium tuberculosis and non- tuberculous mycobacterial infections has placed ever-increasing importance on discovering... |
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SubjectTerms | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Humans Meropenem Mycobacterium tuberculosis Structure-Activity Relationship Tuberculosis, Multidrug-Resistant |
Title | Structure–Activity Relationship of Penem Antibiotic Side Chains Used against Mycobacteria Reveals Highly Active Compounds |
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