Mechanisms of SARS-CoV‑2 Evolution Revealing Vaccine-Resistant Mutations in Europe and America

• Published in: The journal of physical chemistry letters Vol. 12; no. 49; pp. 11850 - 11857
• Main Authors: Wang, Rui, Chen, Jiahui, Wei, Guo-Wei
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 16.12.2021
• Subjects: Americas; Angiotensin-Converting Enzyme 2 - chemistry; Angiotensin-Converting Enzyme 2 - metabolism; Antibodies, Neutralizing - immunology; COVID-19 - diagnosis; COVID-19 - prevention & control; COVID-19 - virology; COVID-19 Vaccines - administration & dosage; Europe; Evolution, Molecular; Humans; Mutation; Physical Insights into Materials and Molecular Properties; Protein Binding; Protein Domains - genetics; SARS-CoV-2 - isolation & purification; SARS-CoV-2 - metabolism; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Spike Glycoprotein, Coronavirus - metabolism; Vaccination; Americas; Europe

The importance of understanding SARS-CoV-2 evolution cannot be overlooked. Recent studies confirm that natural selection is the dominating mechanism of SARS-CoV-2 evolution, which favors mutations that strengthen viral infectivity. Here, we demonstrate that vaccine-breakthrough or antibody-resistant...