Unravelling influenza correlates of protection: lessons from human A/H1N1 Challenge

Mucosal immunity is important in protecting from upper respiratory tract influenza infection. Human challenge provides a unique model to define correlates of protection with baseline immune responses being correlated to the quantity and length of viral shedding and clinical outcomes. Here, we discus...

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Bibliographic Details
Published inmBio Vol. 15; no. 5; p. e0006424
Main Authors Cox, Rebecca Jane, Pathirana, Rishi
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 08.05.2024
Subjects
Animals
antibody
Commentary
correlate of protection
Humans
Immunity, Mucosal
Immunology
Influenza A Virus, H1N1 Subtype - immunology
Influenza Vaccines - administration & dosage
Influenza Vaccines - immunology
Influenza, Human - immunology
Influenza, Human - prevention & control
Influenza, Human - virology
mucosal immunity
Virus Shedding
correlate of protection
antibody
mucosal immunity
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Summary:Mucosal immunity is important in protecting from upper respiratory tract influenza infection. Human challenge provides a unique model to define correlates of protection with baseline immune responses being correlated to the quantity and length of viral shedding and clinical outcomes. Here, we discuss recent work on mucosal and systemic correlates of protection (R. Bean, L. T. Giurgea, A. Han, L. Czajkowski, et al., mBio 15:e02372-23, 2024, https://doi.org/10.1128/mbio.02372-23) and place it in the context of previous work on mucosal immunity. We also discuss the importance of standardized assays to allow global comparison of relevant immune responses in defining correlates of protection. Correlates of protection are important for designing next-generation broadly protective influenza vaccines.
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The authors declare no conflict of interest.
ISSN:2150-7511
2150-7511
DOI:10.1128/mbio.00064-24