Diversification of Amidyl Radical Intermediates Derived from C–H Aminopyridylation

• Published in: Organic letters Vol. 24; no. 14; pp. 2762 - 2766
• Main Authors: Maity, Asim, Roychowdhury, Pritam, Herrera, Roberto G, Powers, David C
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 15.04.2022; Amer Chemical Soc
• Subjects: Amination; Catalysis; Chemistry; Chemistry, Organic; Ethers - chemistry; Ketones - chemistry; Physical Sciences; Science & Technology; Stereoisomerism; HETEROCYCLES

The N-activating substituents typically encountered in C–H amination chemistry are challenging to remove and have limited scope for synthetic elaboration. Here, we demonstrate that N-benzylaminopyridinium species provide a platform for synthetic elaboration via reductive N–N bond activation to unvei...