Enantioselective Total Synthesis of the Antitumor Macrolide Rhizoxin D
The convergent, highly enantioselective synthesis of rhizoxin D, a natural product possessing potent antitumor and antifungal bioactivity, is described. The C(1)−C(9) fragment of the molecule was synthesized utilizing a threefold pseudosymmetric intermediate ultimately derived from γ-butyrolactone....
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Published in | Journal of organic chemistry Vol. 68; no. 11; pp. 4215 - 4234 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
30.05.2003
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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