Developments in Glycopeptide Antibiotics

• Published in: ACS infectious diseases Vol. 4; no. 5; pp. 715 - 735
• Main Authors: Blaskovich, Mark A. T, Hansford, Karl A, Butler, Mark S, Jia, ZhiGuang, Mark, Alan E, Cooper, Matthew A
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 11.05.2018
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Drug Development - methods; Drug Discovery; Drug Resistance, Bacterial; Glycopeptides - chemistry; Glycopeptides - pharmacology; Gram-Positive Bacteria - drug effects; Gram-Positive Bacterial Infections - drug therapy; Gram-Positive Bacterial Infections - microbiology; Humans; Molecular Structure; Review; Structure-Activity Relationship; vancomycin; glycopeptides; antimicrobial resistance; antibiotics

Glycopeptide antibiotics (GPAs) are a key weapon in the fight against drug resistant bacteria, with vancomycin still a mainstream therapy against serious Gram-positive infections more than 50 years after it was first introduced. New, more potent semisynthetic derivatives that have entered the clinic...