Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease

• Published in: JAMA neurology Vol. 70; no. 3; p. 320
• Main Authors: Protas, Hillary D, Chen, Kewei, Langbaum, Jessica B S, Fleisher, Adam S, Alexander, Gene E, Lee, Wendy, Bandy, Daniel, de Leon, Mony J, Mosconi, Lisa, Buckley, Shannon, Truran-Sacrey, Diana, Schuff, Norbert, Weiner, Michael W, Caselli, Richard J, Reiman, Eric M
• Format: Journal Article
• Language: English
• Published: United States 01.03.2013
• Subjects: Aged; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Cognition - physiology; Cohort Studies; Female; Genetic Predisposition to Disease - genetics; Glucose - metabolism; Gyrus Cinguli - metabolism; Hippocampus - metabolism; Hippocampus - pathology; Humans; Longitudinal Studies; Male; Middle Aged; Neuropsychological Tests; Organ Size; Risk

To characterize and compare measurements of the posterior cingulate glucose metabolism, the hippocampal glucose metabolism, and hippocampal volume so as to distinguish cognitively normal, late-middle-aged persons with 2, 1, or 0 copies of the apolipoprotein E (APOE) ε4 allele, reflecting 3 levels of...