An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment

• Published in: ACS infectious diseases Vol. 8; no. 6; pp. 1107 - 1115
• Main Authors: Martín-Escolano, Javier, Marín, Clotilde, Rosales, María J., Tsaousis, Anastasios D., Medina-Carmona, Encarnación, Martín-Escolano, Rubén
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 10.06.2022
• Subjects: Review; genetic diversity; target product profile; life cycle; drug discovery; morphological forms; Chagas disease; tropism; evolution model; Trypanosoma cruzi

Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies CD as the most prevalent of poverty-promoting neglected tropical diseases, the most important parasitic one, and the third...