Anti-SARS-CoV‑2 Potential of Artemisinins In Vitro

• Published in: ACS infectious diseases Vol. 6; no. 9; pp. 2524 - 2531
• Main Authors: Cao, Ruiyuan, Hu, Hengrui, Li, Yufeng, Wang, Xi, Xu, Mingyue, Liu, Jia, Zhang, Huanyu, Yan, Yunzheng, Zhao, Lei, Li, Wei, Zhang, Tianhong, Xiao, Dian, Guo, Xiaojia, Li, Yuexiang, Yang, Jingjing, Hu, Zhihong, Wang, Manli, Zhong, Wu
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 11.09.2020
• Subjects: Animals; Antimalarials - pharmacology; Antiviral Agents - pharmacology; Artemisinins - pharmacology; Betacoronavirus - drug effects; Chlorocebus aethiops; Coronavirus Infections - drug therapy; Coronavirus Infections - virology; COVID-19; Drug Discovery; Drug Repositioning; Drugs, Chinese Herbal - pharmacology; Pandemics; Pneumonia, Viral - drug therapy; Pneumonia, Viral - virology; SARS-CoV-2; Vero Cells; artemisinin; COVID-19; SARS-CoV-2; drug repurposing; antiviral drug

The discovery of novel drug candidates with anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) potential is critical for the control of the global COVID-19 pandemic. Artemisinin, an old antimalarial drug derived from Chinese herbs, has saved millions of lives. Artemisinins are a clust...