Isolation and identification of a direct-acting mutagen in diesel-exhaust particulates

Diesel exhaust particulates contain certain Chemicals that are directly mutagenic in the Ames test. The isolation, identification, and synthesis of one direct-acting mutagen, pyrene-3,4-dicarboxylic acid anhydride, from a sample of diesel exhaust particulates is described. Although the compound is o...

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Published inEnvironmental science & technology Vol. 14; no. 12; pp. 1505 - 1509
Main Authors Rappaport, Stephen M, Wang, Y. Y, Wei, Eddie T, Sawyer, Robert, Watkins, Bruce E, Rapoport, Henry
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.12.1980
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Summary:Diesel exhaust particulates contain certain Chemicals that are directly mutagenic in the Ames test. The isolation, identification, and synthesis of one direct-acting mutagen, pyrene-3,4-dicarboxylic acid anhydride, from a sample of diesel exhaust particulates is described. Although the compound is only weakly mutagenic in the Ames test, it is speculated that it is but one of a class of mutagenic dicarboxylic acid anhydrides of various polynuclear aromatic hydrocarbons in diesel exhausts.
Bibliography:ark:/67375/TPS-S60MBJ8W-1
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ISSN:0013-936X
1520-5851
DOI:10.1021/es60172a016