Quadruplex-Interactive Agents as Telomerase Inhibitors: Synthesis of Porphyrins and Structure−Activity Relationship for the Inhibition of Telomerase - Shi, Dong-Fang; Wheelhouse, Richard T; Sun, Daekyu; Hurley, Laurence H (Journal of medicinal chemistry, 2001)
Keywords: Antineoplastic agents; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biological and medical sciences; Cell-Free System; Chemistry, Medicinal; DNA - chemistry; Enzyme Inhibitors - chemical synthesis; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; G-Quadruplexes; General aspects; HeLa Cells; Humans; Life Sciences & Biomedicine; Medical sciences; Models, Molecular; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Porphyrins - chemical synthesis; Porphyrins - chemistry; Porphyrins - pharmacology; Pyridines - chemistry; Pyrroles - chemistry; Science & Technology; Structure-Activity Relationship; Telomerase - antagonists & inhibitors; PYRROLIC COMPOUNDS; TARGET; CATIONIC PORPHYRINS; FRAGILITY; DNA; CHEMISTRY; SEPARATION; IDENTIFICATION; BINDING; DERIVATIVES; Antineoplastic agent; Pentacyclic compound; Human; Organic cation; Enzyme; Nitrogen heterocycle; Iminium compounds; Benzene derivatives; Enzyme inhibitor; Molecular interaction; In vitro; Modeling; Telomere; Tetrad; Macrocycle; Pyridine derivatives; Biological fixation; Structure activity relation; Molecular model; Aromatic compound; Mechanism of action; Chemical synthesis; Telomerase