The antagonistic transcription factors, EspM and EspN, regulate the ESX-1 secretion system in M. marinum

• Published in: mBio Vol. 15; no. 4; p. e0335723
• Main Authors: Nicholson, Kathleen R, Cronin, Rachel M, Prest, Rebecca J, Menon, Aruna R, Yang, Yuwei, Jennisch, Madeleine K, Champion, Matthew M, Tobin, David M, Champion, Patricia A
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 10.04.2024
• Subjects: Animals; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; ESX-1; Microbial Pathogenesis; Mycobacterium; Mycobacterium marinum - metabolism; Mycobacterium tuberculosis - metabolism; regulation; Research Article; transcription; Transcription Factors - genetics; Transcription Factors - metabolism; Tuberculosis - microbiology; type VII secretion; Type VII Secretion Systems - genetics; Type VII Secretion Systems - metabolism; Zebrafish; Mycobacterium; regulation; transcription; type VII secretion; ESX-1

Bacterial pathogens use protein secretion systems to transport virulence factors and regulate gene expression. Among pathogenic mycobacteria, including and , the ESAT-6 system 1 (ESX-1) secretion is crucial for host interaction. Secretion of protein substrates by the ESX-1 secretion system disrupts...