Molecular Characterization of Zebrafish Embryogenesis via DNA Microarrays and Multiplatform Time Course Metabolomics Studies

• Published in: Journal of proteome research Vol. 10; no. 11; pp. 5102 - 5117
• Main Authors: Soanes, Kelly H, Achenbach, John C, Burton, Ian W, Hui, Joseph P. M, Penny, Susanne L, Karakach, Tobias K
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 04.11.2011
• Subjects: Algorithms; Amino Acids - metabolism; Animals; Blastula - metabolism; Fish Proteins - genetics; Gastrula - metabolism; Gene Expression; Gene Expression Profiling; Magnetic Resonance Spectroscopy; Metabolomics; Multivariate Analysis; Oligonucleotide Array Sequence Analysis; Principal Component Analysis; Zebrafish - embryology; Zebrafish - genetics; Zebrafish - metabolism; data fusion; NMR; embryogenesis; Danio rerio; time course metabolomics and transcriptomics; multivariate curve resolution; LC−MS

One of the greatest strengths of “-omics” technologies is their ability to capture a molecular snapshot of multiple cellular processes simultaneously. Transcriptomics, proteomics, and metabolomics have, individually, been used in wide-ranging studies involving cell lines, tissues, model organisms, a...