Catalytic Diverse Radical-Mediated 1,2-Cyanofunctionalization of Unactivated Alkenes via Synergistic Remote Cyano Migration and Protected Strategies

• Published in: Organic letters Vol. 18; no. 23; pp. 6026 - 6029
• Main Authors: Wang, Na, Li, Lei, Li, Zhong-Liang, Yang, Ning-Yuan, Guo, Zhen, Zhang, Hong-Xia, Liu, Xin-Yuan
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 02.12.2016; Amer Chemical Soc
• Subjects: alkenes; chemical reactions; Chemistry; Chemistry, Organic; free radicals; ketones; moieties; nitriles; Physical Sciences; Science & Technology; VISIBLE-LIGHT; ORGANIC-SYNTHESIS; ALPHA-PERACETOXYNITRILES; REDUCTIVE DECYANATION; LIGHT PHOTOREDOX CATALYSIS; ATOM-TRANSFER; CARBONYL-COMPOUNDS; C-H FUNCTIONALIZATION; TRIFLUOROMETHYLTHIOLATION REACTIONS; FLUOROALKYLSULFONYL CHLORIDES

A catalytic radical protocol for 1,2-cyanofunctionalization of unactivated alkenes involving remote cyano migration triggered by addition of diverse carbon- and heteroatom-centered radicals to alkenes has been developed. This powerful strategy provides a diverse platform for the collection of a vari...