Cp-Free Cobalt-Catalyzed C–H Activation/Annulations by Traceless N,O‑Bidentate Directing Group: Access to Isoquinolines

• Published in: Organic letters Vol. 21; no. 8; pp. 2863 - 2866
• Main Authors: Li, Xiao-Cai, Du, Cong, Zhang, He, Niu, Jun-Long, Song, Mao-Ping
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 19.04.2019; Amer Chemical Soc
• Subjects: alkynes; carbon-hydrogen bond activation; carboxylic acids; chemical bonding; chemical reactions; chemical structure; Chemistry; Chemistry, Organic; isoquinolines; oxidants; Physical Sciences; Science & Technology; FUNCTIONALIZATION; MILD; SUBSTITUTED ISOQUINOLINES; 4+2 ANNULATION; O BOND; IMINES; BOND FORMATION; C(SP)-H; ALKYNES

N,O-Bidentate directing-enabled, traceless heterocycle synthesis is described via Cp*-free cobalt-catalyzed C–H activation/annulation. The weakly coordinating nature of the carboxylic acid was employed for the preparation of isoquinolines. Meanwhile, the N–O bond of the α-imino-oxy acid can serve as...