An Intermolecular Azidoheteroarylation of Simple Alkenes via Free-Radical Multicomponent Cascade Reactions

• Published in: Organic letters Vol. 19; no. 20; pp. 5649 - 5652
• Main Authors: Liu, Zhi, Liu, Zhong-Quan
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 20.10.2017; Amer Chemical Soc
• Subjects: alkenes; azides; chemical structure; Chemistry; Chemistry, Organic; derivatization; drugs; Physical Sciences; Science & Technology; CENTERED RADICALS; C-H ALKYLATION; SODIUM TRIFLUOROMETHANESULFINATE; CONVENIENT ACCESS; REACTION SYSTEM; PYRIDINE N-OXIDES; CATALYZED AZIDATION; BETA-KETO-ESTERS; ORGANIC AZIDES; UNACTIVATED ALKENES

Based upon a radical polar effect, an intermolecular azidoheteroarylation of simple alkenes via a metal-free radical multicomponent cascade process was achieved. It allows a mild, rapid, and step-economic access to a broad range of azidoalkylated heteroaromatics. Given the diversity in transformatio...