Exaggerated platelet reactivity in major depression

• Published in: The American journal of psychiatry Vol. 153; no. 10; p. 1313
• Main Authors: Musselman, D L, Tomer, A, Manatunga, A K, Knight, B T, Porter, M R, Kasey, S, Marzec, U, Harker, L A, Nemeroff, C B
• Format: Journal Article
• Language: English
• Published: United States 01.10.1996
• Subjects: Adult; Annexin A5 - immunology; Annexin A5 - physiology; Antibodies, Monoclonal - immunology; Depressive Disorder - blood; Depressive Disorder - immunology; Epitopes - immunology; Female; Flow Cytometry; Humans; Male; Middle Aged; Platelet Activation - immunology; Platelet Activation - physiology; Platelet Aggregation - immunology; Platelet Aggregation - physiology; Posture - physiology; Rest

This study investigated whether depressed patients exhibit exaggerated platelet reactivity. In vivo platelet activation, secretion, and dose-response aggregation were measured in 12 depressed patients and eight normal comparison subjects after overnight bed rest and following orthostatic challenge....