Exaggerated platelet reactivity in major depression
This study investigated whether depressed patients exhibit exaggerated platelet reactivity. In vivo platelet activation, secretion, and dose-response aggregation were measured in 12 depressed patients and eight normal comparison subjects after overnight bed rest and following orthostatic challenge....
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| Published in | The American journal of psychiatry Vol. 153; no. 10; p. 1313 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.10.1996
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| Subjects | |
| Online Access | Get more information |
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| Abstract | This study investigated whether depressed patients exhibit exaggerated platelet reactivity.
In vivo platelet activation, secretion, and dose-response aggregation were measured in 12 depressed patients and eight normal comparison subjects after overnight bed rest and following orthostatic challenge.
The depressed patients exhibited increased platelet activation at baseline, demonstrated by increased binding of monoclonal antibody (moAb) annexin V protein reacting with prothrombinase complex binding sites. Following orthostatic challenge, the depressed patients exhibited increases in binding of moAbs PAC1 and anti-LIBS1 against activated glycoprotein IIb/IIIa and GE12 against P-selectin expressed upon secretion. The normal comparison subjects exhibited increases in platelet activation only with GE12.
Depressed patients exhibit enhanced baseline platelet activation and responsiveness in comparison with normal subjects. Heightened susceptibility to platelet activation may be a mechanism by which depression is a significant risk factor for ischemic heart and cerebrovascular disease and/or mortality after myocardial infarction. |
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| AbstractList | This study investigated whether depressed patients exhibit exaggerated platelet reactivity.
In vivo platelet activation, secretion, and dose-response aggregation were measured in 12 depressed patients and eight normal comparison subjects after overnight bed rest and following orthostatic challenge.
The depressed patients exhibited increased platelet activation at baseline, demonstrated by increased binding of monoclonal antibody (moAb) annexin V protein reacting with prothrombinase complex binding sites. Following orthostatic challenge, the depressed patients exhibited increases in binding of moAbs PAC1 and anti-LIBS1 against activated glycoprotein IIb/IIIa and GE12 against P-selectin expressed upon secretion. The normal comparison subjects exhibited increases in platelet activation only with GE12.
Depressed patients exhibit enhanced baseline platelet activation and responsiveness in comparison with normal subjects. Heightened susceptibility to platelet activation may be a mechanism by which depression is a significant risk factor for ischemic heart and cerebrovascular disease and/or mortality after myocardial infarction. |
| Author | Manatunga, A K Tomer, A Porter, M R Kasey, S Musselman, D L Nemeroff, C B Knight, B T Harker, L A Marzec, U |
| Author_xml | – sequence: 1 givenname: D L surname: Musselman fullname: Musselman, D L organization: Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA – sequence: 2 givenname: A surname: Tomer fullname: Tomer, A – sequence: 3 givenname: A K surname: Manatunga fullname: Manatunga, A K – sequence: 4 givenname: B T surname: Knight fullname: Knight, B T – sequence: 5 givenname: M R surname: Porter fullname: Porter, M R – sequence: 6 givenname: S surname: Kasey fullname: Kasey, S – sequence: 7 givenname: U surname: Marzec fullname: Marzec, U – sequence: 8 givenname: L A surname: Harker fullname: Harker, L A – sequence: 9 givenname: C B surname: Nemeroff fullname: Nemeroff, C B |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8831440$$D View this record in MEDLINE/PubMed |
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| PublicationTitle | The American journal of psychiatry |
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| Snippet | This study investigated whether depressed patients exhibit exaggerated platelet reactivity.
In vivo platelet activation, secretion, and dose-response... |
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| SubjectTerms | Adult Annexin A5 - immunology Annexin A5 - physiology Antibodies, Monoclonal - immunology Depressive Disorder - blood Depressive Disorder - immunology Epitopes - immunology Female Flow Cytometry Humans Male Middle Aged Platelet Activation - immunology Platelet Activation - physiology Platelet Aggregation - immunology Platelet Aggregation - physiology Posture - physiology Rest |
| Title | Exaggerated platelet reactivity in major depression |
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